Modelling biphasic hormetic dose responses to predict sub-NOAEL effects using plant biology as an example

Belz, Regina G.; Duke, Stephen O.

doi:10.1016/j.cotox.2022.01.003

Cited by 33 publications

(15 citation statements)

References 40 publications

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“…The hormesis significance parameter f in this model was calculated to be 1.45, which is equal to the rate of increase in response to low glyphosate exposure. 8 To date, low rates of glyphosate have not been recommended as growth stimulants for crops, as the hormetic dose can vary considerably and is difficult to predict. 43,44 Our results will contribute to the understanding of how glyphosate hormesis occurs and to the evaluation of the potential use of glyphosate to stimulate plant growth based on the hormesis model.…”

Section: Discussionmentioning

confidence: 99%

“…Doses below x 1 are subhormetic and without measurable mean response differing from that of control; doses above x 3 cause a toxic response. 8 Data are represented as mean values ± standard deviation. leaves were ground in ice-cold buffer containing 20 mM Tricine (pH 7.6) and 0.4 M sorbitol, filtered, and centrifuged at 5000×g for 5 min at 4 °C.…”

Section: Thylakoid Membrane Preparationmentioning

confidence: 99%

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Glyphosate hormesis stimulates tomato (Solanum lycopersicum L.) plant growth and enhances tolerance against environmental abiotic stress by triggering nonphotochemical quenching

Wang,

Cui,

et al. 2024

Pest Management Science

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BackgroundGlyphosate is the most widely applied herbicide in the world. Hormesis caused by low glyphosate doses has been widely documented in many plant species. However, the specific adaptative mechanism of plants responding to glyphosate hormesis stimulation remains unclear. This study focused on the biphasic relationship between glyphosate dose and tomato plant growth and how glyphosate hormesis stimulates plant growth and enhances tolerance to environmental stress.ResultsWe constructed a hormesis model to describe the biphasic relationship with a maximal stimulation (MAX) of 162% above control by glyphosate at 0.063 g ha−1. Low‐dose glyphosate increased photosynthetic pigment contents and improve photosynthetic efficiency, leading to plant growth stimulation. We also found that glyphosate hormesis enhanced plant tolerance to diuron (DCMU; a representative photosynthesis inhibitor) by triggering the non‐photochemical chlorophyll fluorescence quenching (NPQ) reaction to dissipate excess energy stress from photosystem II (PSII). Transcriptomic analysis and quantitative real‐time PCR results revealed that the photosynthesis–antenna proteins pathway was the most sensitive to glyphosate hormesis, and PsbS (encoding photosystem II subunit S), ZEP (encoding zeaxanthin epoxidase), and VDE (encoding violaxanthin de‐epoxidase) involved in NPQ played crucial roles in the plant response to glyphosate hormesis.ConclusionThese results provide novel insights into the mechanisms of plant hormesis and is meaningful to the application of glyphosate hormesis in agriculture.This article is protected by copyright. All rights reserved.

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Section: Discussionmentioning

confidence: 99%

Section: Thylakoid Membrane Preparationmentioning

confidence: 99%

Glyphosate hormesis stimulates tomato (Solanum lycopersicum L.) plant growth and enhances tolerance against environmental abiotic stress by triggering nonphotochemical quenching

Wang,

Cui,

et al. 2024

Pest Management Science

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“…Hormesis effects occur in various organisms, and to various degrees, and are induced by different types of chemicals and environmental stimuli. The quantitative characteristics of hormesis are independent of biological models, biological tissue levels, stressors, and the mode of action 6,7 . Hormesis quantitatively describes biological plasticity, which is fundamental to all biological systems.…”

Section: Introductionmentioning

confidence: 99%

“…The quantitative characteristics of hormesis are independent of biological models, biological tissue levels, stressors, and the mode of action. 6,7 Hormesis quantitatively describes biological plasticity, which is fundamental to all biological systems. Through a various set of structure and modes of action, plants can predict environmental challenges and adjust to stress.…”

Section: Introductionmentioning

confidence: 99%

Hormesis effects in tomato plant growth and photosynthesis due to acephate exposure based on physiology and transcriptomic analysis

Sun

Wang

et al. 2023

Pest Management Science

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BACKGROUND: Hormesis is a common phenomenon in toxicology described as low-dose stimulation due to a toxin which causes inhibition at a high dose. Pesticide hormesis in plants has attracted considerable research interest in recent years; however, the specific mechanism has not yet been clarified. Acephate is an organophosphorus insecticide that is used worldwide. Here, hormesis in tomato (Solanum lycopersicum L.) plant growth and photosynthesis after acephate exposure is confirmed, as stimulation occurred at low stress levels, whereas inhibition occurred after exposure to high concentrations.RESULTS: We found that low acephate concentration (5-fold lower than recommended application dosage) could enhance chlorophyll biosynthesis and stimulate photosynthesis effects, and thus improve S. lycopersicum growth. A high level of acephate (5-fold higher than recommended application dosage) stress inhibited chlorophyll accumulation, decreased photosystem II efficiency and blocked antioxidant reactions in leaves, increasing reactive oxygen species levels and damaging plant growth. Transcriptomic analysis and quantitative real-time PCR results revealed that the photosynthesisantenna proteins pathway played a crucial role in the hormesis effect, and that LHCB7 as well as LHCP from the pathway were the most sensitive to acephate hormesis. CONCLUSION: Our results showed that acephate could induce hormesis in tomato plant growth and photosynthesis, and that photosystem II and the photosynthesisantenna proteins pathway played important roles in hormesis. These results provide novel insights into the scientific and safe application of chemical pesticides, and new guidance for investigation into utilizing pesticide hormesis in agriculture.

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“…This is crucial for the accurate interpretation of results and for guiding future herbicidal usage decisions [ 32 , 33 ]. Promoting studies and conservation efforts are essential to preserve and tap into the potential of T. ciliata , utilizing sub-doses of glyphosate for growth stimulation through the hormesis effect [ 34 , 35 ]. However, by observing the imminent influence of these chemicals on plants, the use of plant species as bioindicators has emerged as an important alternative for assessing the potential impacts of this herbicide on biota and in biomonitoring of exposures [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Hormetic Effect Caused by Sublethal Doses of Glyphosate on Toona ciliata M. Roem

de Faria,

Carlos,

Jakelaitis

et al. 2023

Plants

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This study aimed to evaluate the response of Toona ciliata seedlings to sublethal doses of glyphosate. The increasing use of glyphosate in agriculture concerns the scientific community, as the drift of this pollutant into aquatic systems or atmospheric currents can affect non-target species. Therefore, we need to understand how non-target species respond to small doses of this herbicide. T. ciliata seedlings (clone BV-1110) were exposed to sublethal doses of glyphosate (0, 9.6, 19.2, 38.4, 76.8 g ae ha−1). Anatomical, physiological, and photochemical analyses were performed 60 days after herbicide application, and growth assessments were carried out after 160 days of cultivation. We found that sublethal doses of glyphosate above 19.2 g ae ha−1 induced toxicity symptoms in Toona ciliata leaves. These symptoms were mild in some cases, such as chlorosis, but severe in other cases, such as tissue necrosis. We observed a positive relationship between increased plant height and photochemical yield with plant exposure to sub-doses 9.6 and 19.2 g ae ha−1. A sublethal dose of 38.4 g ae ha−1 improved the photosynthetic rate and carboxylation efficiency. Thus, we confirmed the hypothesis of a hormetic effect when T. ciliata was exposed to sub-doses of glyphosate equal to or lower than 38.4 g ae ha−1. However, the sublethal dose of 76.8 g ae ha−1 must be considered toxic, impacting photosynthetic activity and, consequently, the height of T. ciliata. The stem diameter of T. ciliata responded positively to increasing glyphosate doses. This occurs to compensate for the negative effect of glyphosate on water absorption. Further research will provide valuable information for harnessing the potential benefits of hormesis to improve the productivity of T. ciliata.

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Modelling biphasic hormetic dose responses to predict sub-NOAEL effects using plant biology as an example

Cited by 33 publications

References 40 publications

Glyphosate hormesis stimulates tomato (Solanum lycopersicum L.) plant growth and enhances tolerance against environmental abiotic stress by triggering nonphotochemical quenching

Glyphosate hormesis stimulates tomato (Solanum lycopersicum L.) plant growth and enhances tolerance against environmental abiotic stress by triggering nonphotochemical quenching

Hormesis effects in tomato plant growth and photosynthesis due to acephate exposure based on physiology and transcriptomic analysis

Hormetic Effect Caused by Sublethal Doses of Glyphosate on Toona ciliata M. Roem

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