The present study, for the first time, examined land-use land cover (LULC), changes using GIS, between 2000 and 2018 for the IIT Bombay campus, India. Objective was to evaluate hydro-ecological balance inside campus by determining spatio-temporal disparity between hydrological parameters (rainfall-runoff processes), ecological components (forest, vegetation, lake, barren land), and anthropogenic stressors (urbanization and encroachments). High-resolution satellite imageries were generated for the campus using Google Earth Pro, by manual supervised classification method. Rainfall patterns were studied using secondary data sources, and surface runoff was estimated using SCS-CN method. Additionally, reconnaissance surveys, ground-truthing, and qualitative investigations were conducted to validate LULC changes and hydro-ecological stability. LULC of 2018 showed forest, having an area cover of 52%, as the most dominating land use followed by built-up (43%). Results indicated that the area under built-up increased by 40% and playground by 7%. Despite rapid construction activities, forest cover and Powai lake remained unaffected. This anomaly was attributed to the drastically declining barren land area (up to ~ 98%) encompassing additional construction activities. Sustainability of the campus was demonstrated with appropriate measures undertaken to mitigate negative consequences of unwarranted floods owing to the rise of 6% in the forest cover and a decline of 21% in water hyacinth cover over Powai lake. Due to this, surface runoff (~ 61% of the rainfall) was observed approximately consistent and being managed appropriately despite major alterations in the LULC. Study concluded that systematic campus design with effective implementation of green initiatives can maintain a hydro-ecological balance without distressing the environmental services.