Modelling of Cells Bioenergetics

Abstract

This paper presents an integrated model describing the control of Saccharomyces cerevisiae yeast cells bioenergetics. This model describes the oxidative and respirofermentative metabolism. The model assumes that the mitochondria of the Saccharomyces cerevisiae cells are charged with NADH during the tricarboxylic acid cycle, and NADH is discharged from mitochondria later in the electron transport system. Selected effects observed in the Saccharomyces cerevisiae eucaryotic cells, including the Pasteur's and Crabtree effects, are also modeled.

Bioenergetics of life, disease and death phenomena

“…The results presented in this article are based on unified cell bioenergetics (UCB) (Kasperski 2008 ; Kasperski and Kasperska 2013 ). In accordance with UCB, the direct cause of metabolism regulation is positive feedback for ATP (fATP).…”

“…The unified cell bioenergetics (UCB) is an extension of integrated cell bioenergetics and allows for the interpretation of several main cell bioenergetic effects, that can occur during the metabolism of eukaryotic cells, inclusive of Pasteur’s, Crabtree, Kluyver and glucose effects (Kasperski 2008 ; Kasperski and Kasperska 2013 ). According to UCB the occurrence of cellular bioenergetic effects and certain diseases are dependent on the intramitochondrial NAHD level.…”

Theoretical Study and Optimization of the Biochemical Reaction Process by Means of Feedback Control Strategy

“…is implies that the trajectories of system (2) intersecting with the trajectories of system (13) pass through the trajectories of system (13) from the le to the right. In addition, the trajectory of system (13) passing through , set ) (i.e., in (14)) intersects the line…”

“…During the growth of microorganisms, the dissolved oxygen concentration depends on several factors, among them the biomass concentration, the concentration and type of substrate used, and the bioprocess conditions. Because a low level of dissolved oxygen concentration decreases the biomass yield and the speci�c growth rate, it is necessary to monitor and control the DOC level so that it stays within the appropriate range [14].…”

A stochastic model for microbial fermentation process under Gaussian white noise environment

“…We take the production of L-glutamic acid (LGA) by Corynebacterium glutamicum as an example, where LGA is produced commercially under aerobic fermentation conditions, the C. glutamicum undergo stresses, and the specific growth rate of C. glutamicum is continuously decreasing with the increase of product concentration (i.e. product inhibition occurs) and a low level of dissolved oxygen concentration ( [5,18,4,7,8]). On the base of formal kinetic approach, Bona and Moser [3] proposed a mathematical model for L-glutamic acid production process, which included formal growth inhibition with product and production repression with substrate.…”