The accelerating processes of regionalization and glocalization of national economies are gradually changing the globalization path of development, as they fit more into the transforming picture of the new world order, in which not only geopolitical and economic aspects are changing, but also approaches to understanding the essence and practical implementation of the concepts of sustainable development, environmentally friendly development and socially oriented behavior. But despite a fairly large-scale change in development trajectories, absolutely all subjects of the world economy are influenced by digitalization trends, which are becoming almost the main tools for implementing political, economic and other types of national strategies. Thus, the formation of regional clusters is occurring on the basis of the influence of two strong factors at once – the widespread glocalization of the economy and the digitalization of all spheres of society, enabling regions to strengthen their specific territorial competitive advantages, including through the use of modern digital tools, since despite the ambiguity of the goals of Industry 4.0, it is impossible to avoid its influence, which means that it is necessary to use the advantages that it provides for the development of both individual economic entities and their associations within cluster formations. The paper attempts to consider the digital tools currently available for use by regional clusters and find out what competitive advantages their competent application can provide.