Modelling the effect of intervillous flow on solute transfer based on 3D imaging of the human placental microstructure

Perazzolo, Simone; Lewis, Rohan M.; Sengers, Bram G.

doi:10.1016/j.placenta.2017.10.003

Cited by 28 publications

(38 citation statements)

References 26 publications

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“…A villous tree density of 0.46 with a branch angle of 24° was found to be optimal for maximising oxygen transport [47,48]. On the other hand, the umbilical cord shape is suggested to be ideal for preserving WSS when under mechanical loading [55], while the drastic changes in feto-capillary diameters were shown to decelerate the flow allowing blood oxygenation [19].…”

Section: Discussionmentioning

confidence: 99%

“…(e)Single terminal villi inside a cylinder of maternal blood [46]. Three-dimensional CLSM-based model of blood flow through several villi [48]. All figures were reproduced with permission.…”

Section: Maternal and Fetal Blood Flowsmentioning

confidence: 99%

“…A way to overcome this is by reconstructing a block of villi, such as in the work of Perazzolo etal. [48]. Three-dimensional reconstructions of IVS from CLSM images were coupled with computational modelling (seeFig.2f).…”

Section: Maternal and Fetal Blood Flowsmentioning

confidence: 99%

“…(d)Flow streamlines and oxygen concentration map in the intervillous space [45]. (e)Oxygen flux in terminal villi due to maternal blood flow [48]. All figures were reproduced with permission.…”

Section: Placental Transport Functionmentioning

confidence: 99%

“…This study predicted a small influence of the villous tree branching generations on the oxygen uptake and a preferential branch angle of 24°. The latest and more sophisticated model, reconstructed a block of CLSM images [48] that included several villi, following the methodology proposed by Plitman Mayo etal. [59].…”

Section: Placental Transport Functionmentioning

confidence: 99%

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Advances in Human Placental Biomechanics

Mayo

2018

Computational and Structural Biotechnology Journal

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Pregnancy complications are a major clinical concern due to the related maternal and fetal morbidity. Many are caused through defective placentation, but research into placental function is difficult, principally because of the ethical limitations associated with the in-vivo organ and the difficulty of extrapolating animal models. Perfused by two separate circulations, the maternal and fetal bloodstreams, the placenta has a unique structure and performs multiple complex functions. Three-dimensional imaging and computational modelling are becoming popular tools to investigate the morphology and physiology of this organ. These techniques bear the potential for better understanding the aetiology and development of placental pathologies, however, their full potential is yet to be exploited. This review aims to summarize the recent insights into placental structure and function by employing these novel techniques.

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Section: Discussionmentioning

confidence: 99%

Section: Maternal and Fetal Blood Flowsmentioning

confidence: 99%

Section: Maternal and Fetal Blood Flowsmentioning

confidence: 99%

Section: Placental Transport Functionmentioning

confidence: 99%

Section: Placental Transport Functionmentioning

confidence: 99%

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Advances in Human Placental Biomechanics

Mayo

2018

Computational and Structural Biotechnology Journal

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Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy

Clark

Lee

James

2020

WIREs Mechanisms of Disease

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In pregnancy, fetal growth is supported by its placenta. In turn, the placenta is nourished by maternal blood, delivered from the uterus, in which the vasculature is dramatically transformed to deliver this blood an ever increasing volume throughout gestation. A healthy pregnancy is thus dependent on the development of both the placental and maternal circulations, but also the interface where these physically separate circulations come in close proximity to exchange gases and nutrients between mum and baby. As the system continually evolves during pregnancy, our understanding of normal vascular anatomy, and how this impacts placental exchange function is limited. Understanding this is key to improve our ability to understand, predict, and detect pregnancy pathologies, but presents a number of challenges, due to the inaccessibility of the pregnant uterus to invasive measurements, and limitations in the resolution of imaging modalities safe for use in pregnancy. Computational approaches provide an opportunity to gain new insights into normal and abnormal pregnancy, by connecting observed anatomical changes from high-resolution imaging to function, and providing metrics that can be observed by routine clinical ultrasound. Such advanced modeling brings with it challenges to scale detailed anatomical models to reflect organ level function. This suggests pathways for future research to provide models that provide both physiological insights into pregnancy health, but also are simple enough to guide clinical focus. We the review evolution of computational approaches to understanding the physiology and pathophysiology of pregnancy in the uterus, placenta, and beyond focusing on both opportunities and challenges.

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Architecture of the Villous Trees

Burton¹

2021

Benirschke's Pathology of the Human Placenta

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Modelling the effect of intervillous flow on solute transfer based on 3D imaging of the human placental microstructure

Abstract: This study suggests that the interplay between maternal flow and villous structure affects the efficiency of placental transfer but predicted that flow rate will be the major determinant of transfer.

Cited by 28 publications

References 26 publications

Advances in Human Placental Biomechanics

Advances in Human Placental Biomechanics

Computational modeling of the interactions between the maternal and fetal circulations in human pregnancy

Architecture of the Villous Trees

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