Modelo de indução de diarréia osmótica em bezerros holandeses

Leal, Marta Lizandra do Rêgo; Cyrillo, Fernanda Cavallini; Mori, Clara Satisuki; Michima, Lílian Emy dos Santos; Nichi, Marcílio; Ortolani, Enrico Lippi; Benesi, Fernando José

doi:10.1590/s0103-84782008000600024

Cited by 9 publications

(16 citation statements)

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“…There was a significant increase in the mean values of rectal body temperature, respiration and heart rates in calves suffered from diarrhea. This observation coincides with previous reports [ 36 , 37 ]. In fact, it appears that a compensatory polypnea in response to acidosis to eliminate the excess of CO 2 in order to reach normal values of pH and tachycardia compensates the hypovolemia due to dehydration during diarrhea [ 38 ].…”

Section: Discussionsupporting

confidence: 94%

“…The increase in WBCs and neutrophilia in calves suffered from diarrhea than apparently healthy group is due to the infection by pathogenic E. coli and Salmonella spp. The significant increase in the hematocrit was observed during scours in other studies [ 36 , 37 , 39 , 40 ]. Hematocrit provides important information about the overall blood volume; in addition, it tended to be higher at birth and then decreased with age.…”

Section: Discussionsupporting

confidence: 66%

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Clinical, hematological and some biochemical alterations during diarrhea in Friesian calves naturally infected with E. coli and Salmonella

Shehta

El-Zahar

Mansour

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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Background This study aimed to assess the clinical and hemato-biochemical changes associated with diarrhea in E. coli and Salmonella pathogens in Friesian bovine calves less than one month old as well as to examine the relationship between Vit D3 and cardiac biomarkers. Results The study was carried out on 43 Friesian calves from a private farm in Ash Sharqia Governorate, 33 diarrheic calves aged 1–14 days with an average body weight 43.7 ± 1.2 kg, and 10 apparently healthy calves were kept as a control group to investigate the clinical and hemato-biochemical profiles. E. coli and Salmonella pathogens were isolated from the diarrheic calves where 76% were E. coli and 24% were Salmonella. Diarrheic calves showed signs of anorexia, weakness, dullness, staggering gait, pale mucous membranes with sunken eyes and dehydration. Analysis of clinical and hemato-biochemical profile of the diarrheic calves revealed significant increase in body temperature, respiratory rate, heart rate, white blood cells, neutrophils, serum potassium, urea, creatinine, ALT, AST, cardiac NT-proBNP and cardiac troponin I with significant decrease in hemoglobin, packed cell volume, erythrocytes, serum Vit D3, sodium, glucose, total protein and albumin concentrations. Conclusions It could be concluded that bacterial diarrhea has a severe negative impact on the clinical and hemato-biochemical profile of the neonatal calves with diarrhea. Serum cardiac biomarkers such as cardiac troponin I (cTn-I) and NT-proBNP were significantly higher in neonatal calves with diarrhea, and there is an important relationship between cardiac biomarkers and vitamin D levels.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 66%

Clinical, hematological and some biochemical alterations during diarrhea in Friesian calves naturally infected with E. coli and Salmonella

Shehta

El-Zahar

Mansour

et al. 2022

Beni-Suef Univ J Basic Appl Sci

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“…Neonatal diarrhea is a major problem in the livestock industry . This form of diarrhea can lead to death of calves because of water electrolyte and acid base imbalances .…”

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confidence: 99%

Intravenous Hypertonic Saline Solution (7.5%) and Oral Electrolytes to Treat of Calves with Noninfectious Diarrhea and Metabolic Acidosis

Leal

Fialho

Cyrillo

et al. 2012

Veterinary Internal Medicne

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Objective: The aim of this study was to compare the efficacy of treating osmotic diarrhea and dehydration in calves with hypertonic saline solution (HSS) IV, isotonic electrolyte solution (IES) PO, and a combination of these 2 solutions (HSS + IES).Experimental Design: Eighteen male calves 8-30 days of age were used to evaluate the efficacy of 3 methods of fluid therapy after induction of osmotic diarrhea and dehydration. The diarrhea and dehydration were induced by administration of saccharose, spironolactone, and hydrochlorothiazide for 48 hours. The animals were randomly divided into 3 experimental groups: Group 1: 7.2% hypertonic saline solution-HSS (5 mL/kg IV); Group 2: oral isotonic electrolyte solution IES (60 mL/kg PO); or Group 3: HSS+IES. Clinical signs and laboratory finding observed 48 hours post-induction (Time 0) included diarrhea, dehydration, lethargy, and metabolic acidosis.Results: Calves treated with HSS + IES experienced decreases in hematocrit, total protein concentration, albumin concentration, urea nitrogen concentration, and plasma volume as well as increases in blood pH, blood bicarbonate concentration, and central venous pressure between 1 and 3 hours post-treatment. These findings also were observed in animals treated with IES, however, at a slower rate than in the HSS + IES-treated animals. Animals treated with HSS continued to display signs of dehydration, lethargy, and metabolic acidosis 24 hours post-treatment.Conclusion: Treatment with a combination of HSS and IES produced rapid and sustainable correction of hypovolemia and metabolic acidosis in calves with noninfections diarrhea and dehydration.

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“…They had free access to water, and after 5 days of life, they received commercial pre-starter ration and coast-cross grass hay (Cynodon dactylon) at will. Osmotic diarrhea and dehydration were induced in all the calves using a standardized protocol (Leal et al, 2008(Leal et al, , 2012. The protocol lasted for 48h with oral administration every 8h.…”

Section: Methodsmentioning

confidence: 99%

Effectiveness of oral electrolyte solutions with different compositions for the treatment of neonatal calves with induced osmotic diarrhea

Bregadioli

Santos

Cerri

et al. 2023

Arq. Bras. Med. Vet. Zootec.

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In a randomized controlled trial, we evaluated the effects of five oral electrolyte solutions (OESs) with different compositions of water, electrolyte, and acid-base balances of diarrheal neonatal calves. Osmotic diarrhea and dehydration were induced with sucrose in milk, spironolactone, and hydrochlorothiazide for 48 h in thirty 10-day old Holstein healthy calves with 43.5 ± 3.80 kg BW who were fed with natural milk. They were allocated to five treatment groups (n=6) based on the administered OES (commercial: OES A, B, C, D; and non-commercial: OES UEL). On the day of treatment, the calves received 6L of OES in two doses apart from milk intakes. Venous blood samples were collected at -48h (start of induction), -24h, 0h (start of the treatment day), 8h, 16h, 24h, 48h, and 72h. TPP, glucose, D-lactate, L-lactate, pH, pCO2, HCO3 -, BE, Na+, K+, Cl-, SID3, SIG, AG, Atot and percentage change in plasma volume (%PV) were measured or calculated and analyzed by two-way repeated measures ANOVA. All the calves developed osmotic diarrhea, mild to moderate dehydration, hyponatremia, relative hyperchloremia, and moderate to severe metabolic acidosis. The tested OESs were well accepted by the calves and effective in reversing dehydration, electrolyte imbalances, and metabolic acidosis. OES D did not completely correct hyponatremia, and SEO B caused transient hyperglycemia. It has been concluded that all the tested OESs are safe and effective for the treatment of diarrhea in calves with moderate degrees of dehydration and metabolic acidosis, which indicates that they have proper compositions for this purpose.

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Modelo de indução de diarréia osmótica em bezerros holandeses

Abstract: II Modelo de indução de diarréia osmótica em bezerros holandeses RESUMO

Cited by 9 publications

References 10 publications

Clinical, hematological and some biochemical alterations during diarrhea in Friesian calves naturally infected with E. coli and Salmonella

Clinical, hematological and some biochemical alterations during diarrhea in Friesian calves naturally infected with E. coli and Salmonella

Intravenous Hypertonic Saline Solution (7.5%) and Oral Electrolytes to Treat of Calves with Noninfectious Diarrhea and Metabolic Acidosis

Effectiveness of oral electrolyte solutions with different compositions for the treatment of neonatal calves with induced osmotic diarrhea

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