Models of Depression a

Mazarati, Andréy

doi:10.1016/b978-0-12-804066-9.00076-6

Cited by 2 publications

(1 citation statement)

References 155 publications

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“…All square waves were 1 msec in duration. Animals received no treatment following stimulation of the perforant path and were included in the study if they remained in SE 10 min after the end of perforant path stimulation 19 . Intermittent stage 1–5 kindling-like seizures, and electrographic seizures that were initially nearly continuous and later became separated by periods of low-voltage activity, continued for many hours.…”

Section: Methodsmentioning

confidence: 99%

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

et al. 2017

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Global expression profiling of neurologic or psychiatric disorders has been confounded by variability among laboratories, animal models, tissues sampled, and experimental platforms, with the result being that few genes demonstrate consistent expression changes. We attempted to minimize these confounds by pooling dentate granule cell transcriptional profiles from 164 rats in seven laboratories, using three status epilepticus (SE) epilepsy models (pilocarpine, kainate, self-sustained SE), plus amygdala kindling. In each epilepsy model, RNA was harvested from laser-captured dentate granule cells from six rats at four time points early in the process of developing epilepsy, and data were collected from two independent laboratories in each rodent model except SSSE. Hierarchical clustering of differentially-expressed transcripts in the three SE models revealed complete separation between controls and SE rats isolated 1 day after SE. However, concordance of gene expression changes in the SE models was only 26–38% between laboratories, and 4.5% among models, validating the consortium approach. Transcripts with unusually highly variable control expression across laboratories provide a ‘red herring’ list for low-powered studies.

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Section: Methodsmentioning

confidence: 99%

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

et al. 2017

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Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior

Zernov,

Popugaeva

2023

IJMS

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The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synaptoprotective signaling pathways, including antagonism of N-methyl-D-aspartate receptor (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic store-operated calcium entry. Positive regulation of TRPC6 channels has been repeatedly shown to be good for memory formation and storage. TRPC6 is mainly expressed in the hippocampus, particularly in the dentate granule cells, cornu Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic interneurons. It has been observed that TRPC6 agonists have a great influence on animal behavior including memory formation and storage The purpose of this review is to collect the available information on the role of TRPC6 in memory formation in various parts of the brain to understand how TRPC6-specific pharmaceutical agents will affect memory in distinct parts of the central nervous system (CNS).

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Models of Depression a

Cited by 2 publications

References 155 publications

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models

Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior

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