Moderate concentrations of supplemental oxygen worsen hypercapnia in obesity hypoventilation syndrome: a randomised crossover study

The Effect of Supplemental Oxygen in Obesity Hypoventilation Syndrome

“…In one study, 28 subjects were exposed to 28% and 50% oxygen concentrations for 20 min 8 and in another study, 24 subjects were exposed to 100% oxygen for 20 min. 7 The arterialized-venous PCO 2 8 and transcutaneous PCO 2 7 increased with oxygen therapy in a subgroup of patients with OHS.…”

“…6 Two experimental studies reported an increase in daytime partial pressure of carbon dioxide (PCO 2 ) with exposure to 20 min of intermediate or high concentrations of supplemental oxygen in a proportion of patients with stable OHS. 7,8 In another study an increase in nocturnal PCO 2 was observed in 11 obese patients with nocturnal hypoventilation treated with low oxygen concentrations during 15 days, although no changes in daytime PCO 2 or clinical symptoms were observed. 9 However, there is no information about medium or long-term treatment efficacy of adding oxygen to treatment strategies typically used in patients with OHS, such as NIV, CPAP, and lifestyle modification.…”

“…The Effect of Supplemental Oxygen in Obesity Hypoventilation Syndrome Juan F. Masa, MD, PhD 1,17 ; Jaime Corral, MD 1,17 ; Auxiliadora Romero, MD 11 ; Candela Caballero, MD 11 ; Joaquin Terán-Santos, MD, PhD 2,17 ; Maria L. Alonso-Álvarez, MD, PhD 2,17 ; Teresa Gomez-Garcia, MD 3 ; Mónica González, MD, PhD 4 ; Soledad López-Martínez, MD 5 ; Pilar De Lucas, MD, PhD 5 ; José M. Marin, MD, PhD 6,17 ; Sergi Marti, MD, PhD 7,17 ; Trinidad Díaz-Cambriles, MD 8,17 ; Eusebi Chiner, MD, PhD 9 ; Miguel Merchan, MStat 1 ; Carlos Egea, MD, PhD 10,17 ; Ana Obeso, MD, MSc 18 ; Babak Mokhlesi, MD, MSc 19 ; on behalf of the Spanish Sleep Network Spanish Sleep Network: Estefanía García-Ledesma, MD 1 ; M-Ángeles Sánchez-Quiroga MD 20 ; Estrella Ordax, MD 2,17 ; Nicolás González-Mangado, MD, PhD 3,17 ; Maria F. Troncoso, MD, PhD 3,17 ; Maria-Ángeles Martinez-Martinez, MD 4 ; Olga Cantalejo, MD 4 ; Elena Ojeda, MD 5 ; Santiago J. Carrizo, MD, PhD 6,17 ; Begoña Gallego, MD, PhD 6 ; Mercedes Pallero, MD 7,17 ; Maria Antonia Ramón, PT, MSC 7,17 ; Josefa Díaz-de-Atauri, MD, PhD 8,…”

To Give or Not To Give - Is that the Question?: The Changing Face of Emergency Oxygen Therapy

“…In OHS (obesity hypoventilation syndrome) a similar message supports the use of oxygen titrated to saturations. Hollier et al [31] in a double blind randomised crossover study demonstrated that breathing moderate concentration of supplemental oxygen in stable OHS worsened hypercapnia and induced acideamia.…”

“…The importance of titrating oxygen to achieve target saturation ranges has become increasingly apparent, with a number of randomised controlled trials indicating that failure to do so, instead over-oxygenating patients presenting with respiratory conditions, can lead to life threatening, if not fatal, respiratory acidosis [15,[29][30][31].…”