Moderate Exercise Blunts Oxidative Stress Induced by Normobaric Hypoxic Confinement

Debevec, Tadej; Pialoux, Vincent; Mekjavic, Igor B.; Eiken, Ola; Mury, Pauline; Millet, Grégoire P.

doi:10.1249/mss.0b013e31829f87ef

Cited by 38 publications

(51 citation statements)

References 37 publications

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“…Details of the exercise testing and training protocol are presented elsewhere [31]. Briefly, all participants performed an incremental test to task failure on an electronically braked cycle-ergometer (Ergo Bike Premium, Daum electronics, Fürth, Germany) prior to the start of the confinement, to assess their baseline aerobic capacity.…”

Section: Methodsmentioning

confidence: 99%

Exercise Training during Normobaric Hypoxic Confinement Does Not Alter Hormonal Appetite Regulation

et al. 2014

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BackgroundBoth exposure to hypoxia and exercise training have the potential to modulate appetite and induce beneficial metabolic adaptations. The purpose of this study was to determine whether daily moderate exercise training performed during a 10-day exposure to normobaric hypoxia alters hormonal appetite regulation and augments metabolic health.MethodsFourteen healthy, male participants underwent a 10-day hypoxic confinement at ∼4000 m simulated altitude (FIO2 = 0.139±0.003%) either combined with daily moderate intensity exercise (Exercise group; N = 8, Age = 25.8±2.4 yrs, BMI = 22.9±1.2 kg·m−2) or without any exercise (Sedentary group; N = 6 Age = 24.8±3.1 yrs, BMI = 22.3±2.5 kg·m−2). A meal tolerance test was performed before (Pre) and after the confinement (Post) to quantify fasting and postprandial concentrations of selected appetite-related hormones and metabolic risk markers. 13C-Glucose was dissolved in the test meal and 13CO2 determined in breath samples. Perceived appetite ratings were obtained throughout the meal tolerance tests.ResultsWhile body mass decreased in both groups (−1.4 kg; p = 0.01) following the confinement, whole body fat mass was only reduced in the Exercise group (−1.5 kg; p = 0.01). At Post, postprandial serum insulin was reduced in the Sedentary group (−49%; p = 0.01) and postprandial plasma glucose in the Exercise group (−19%; p = 0.03). Fasting serum total cholesterol levels were reduced (−12%; p = 0.01) at Post in the Exercise group only, secondary to low-density lipoprotein cholesterol reduction (−16%; p = 0.01). No differences between groups or testing periods were noted in fasting and/or postprandial concentrations of total ghrelin, peptide YY, and glucagon-like peptide-1, leptin, adiponectin, expired 13CO2 as well as perceived appetite ratings (p>0.05).ConclusionThese findings suggest that performing daily moderate intensity exercise training during continuous hypoxic exposure does not alter hormonal appetite regulation but can improve the lipid profile in healthy young males.

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confidence: 99%

Exercise Training during Normobaric Hypoxic Confinement Does Not Alter Hormonal Appetite Regulation

et al. 2014

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“…simulated altitude; Debevec et al 2014). We chose to include a maximal exercise challenge and to push the athletes to exhaustion because (i) elite athletes are well adapted to their exercise modality and (ii) we wanted to assess the redox response in elite healthy athletes (i.e.…”

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confidence: 99%

Effects of exercise on alterations in redox homeostasis in elite male and female endurance athletes using a clinical point-of-care test

Lewis

Towey

Bruinvels

et al. 2016

Appl. Physiol. Nutr. Metab.

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Exercise causes alterations in redox homeostasis (ARH). Measuring ARH in elite athletes may aid in the identification of training tolerance, fatigued states and underperformance. To our knowledge no studies have examined ARH in elite male and female distance runners at sea level. The monitoring of ARH in athletes is hindered by a lack of reliable and repeatable in-the-field testing tools and by the rapid turnaround of results. We examined the effects of various exercise intensities on ARH in healthy (non-overreached) elite male and female endurance athletes using clinical point of care (POC) redox tests, referred to as the free-oxygen-radical-test (FORT; pro-oxidant) and the free-oxygen-radical-defence (FORD; anti-oxidant). Elite male and female endurance athletes (n=22) completed a discontinuous incremental treadmill protocol at submaximal running speeds and a test to exhaustion. Redox measures were analyzed via blood sampling at rest; warm-up; sub-maximal exercise; exhaustion and recovery. FORD was elevated above rest after sub-maximal, and

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“…Peak oxygen consumption (

{\dot{normalV} O}_{2 peak}

) was determined using an incremental cycle test to volitional exhaustion (Ergo Bike Premium, Daum Electronics, Fϋrth, Germany) in normobaric normoxic and normobaric hypoxic conditions. The two tests were conducted in random, counterbalanced order over the course of the familiarization weekend, and separated by 1 day, using methods described previously …”

Section: Methodsmentioning

confidence: 99%

“…The environmental conditions of the confinement area were: 23 ± 1°C, 57 ± 8% relative humidity, 682 ± 4 mm Hg barometric pressure. Hypoxia was maintained using a vacuum pressure swing adsorption system (b‐Cat, Tiel, The Netherlands), described elsewhere . The hypoxic system maintained a fraction of oxygen of 0.139 ± 0.003 (F I O 2 ).…”

Section: Methodsmentioning

confidence: 99%

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Effect of exercise on night periodic breathing and loop gain during hypoxic confinement

et al. 2015

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Background and objective: Hypoxic exercise exacerbates periodic breathing in otherwise healthy, awake humans. Interactions between sleep, exercise and hypoxic exposure have not been fully elucidated. Methods: Fourteen men were confined 10 days to a simulated altitude of 4175 m (FIO2 = 0.139; PIO2 = 88 mm Hg). They were randomly assigned to an exercise intervention of 2 × 60-min cycle exercise/day at 50% of their hypoxia-specific peak power output (exercise, n = 8), or they completed no exercise (control, n = 6, random order). Sleep and breathing were objectively assessed via full polysomnography on night 1, after 14-h acute exposure (N1), and again on night 10 (N10). Results: The exercise group spent more time in light sleep than control on N10 (95% confidence interval (CI): 8.5-15.0%; P = 0.013) and experienced more stage shifts (CI: 13-44; P = 0.023) on both nights compared with control. The exercise group experienced more apnoea-hypopnoea (AH) events per hour compared with control (CI: 1-110; P = 0.046); AH events that were associated with night desaturations were also higher on N1 (exercise: 397 ± 320, control: 124 ± 205, P = 0.047) and N10 (exercise: 375 ± 229, control: 110 ± 138, P = 0.028, CI: 49-489 total events; P = 0.020). The length of hyperpnoea was increased from 12.8 ± 2.2 s on N1 to 14.6 ± 2.7 s on N10 (P = 0.008), and thus, total cycle length also increased (P = 0.002) in both cohorts. Mean pooled duty ratios were 0.68 ± 0.02 on N1 and 0.69 ± 0.02 on N10 (group effect P = 0.617). Conclusion: Daily, moderate-intensity exercise in normobaric hypoxia equivalent to 4175 m exacerbated AH events, and negatively affected sleep architecture in exercisers compared with matched controls.

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Moderate Exercise Blunts Oxidative Stress Induced by Normobaric Hypoxic Confinement

Abstract: These data provide evidence that 2 h of moderate daily exercise training can attenuate the oxidative stress induced by continuous hypoxic exposure.

Cited by 38 publications

References 37 publications

Exercise Training during Normobaric Hypoxic Confinement Does Not Alter Hormonal Appetite Regulation

Exercise Training during Normobaric Hypoxic Confinement Does Not Alter Hormonal Appetite Regulation

Effects of exercise on alterations in redox homeostasis in elite male and female endurance athletes using a clinical point-of-care test

Effect of exercise on night periodic breathing and loop gain during hypoxic confinement

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