Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss

Voltarelli, Vanessa Azevedo; Amano, Mariane Tami; Tobias, Gabriel Cardial; Borges, Gabriela Silva; Oliveira da Paixão, Ailma; Pereira, Marcelo Gomes; Saraiva Câmara, Niels Olsen; Caldeira, Waldir; Ribeiro, Alberto Freitas; Otterbein, Leo Edmond; Negrão, Carlos Eduardo; Turner, James Edward; Brum, Patricia Chakur; Camargo, Anamaria Aranha

doi:10.1016/j.isci.2024.110121

iScience

2024

DOI: 10.1016/j.isci.2024.110121

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Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss

Vanessa Azevedo Voltarelli,

Mariane Tami Amano,

Gabriel Cardial Tobias

et al.

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Regulation of CD8+ T cells by lipid metabolism in cancer progression

Tang,

Chen,

Zuo

et al. 2024

Cell Mol Immunol

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Dysregulation of lipid metabolism is a key characteristic of the tumor microenvironment, where tumor cells utilize lipids for proliferation, survival, metastasis, and evasion of immune surveillance. Lipid metabolism has become a critical regulator of CD8+ T-cell-mediated antitumor immunity, with excess lipids in the tumor microenvironment impeding CD8+ T-cell activities. Considering the limited efficacy of immunotherapy in many solid tumors, targeting lipid metabolism to enhance CD8+ T-cell effector functions could significantly improve immunotherapy outcomes. In this review, we examine recent findings on how lipid metabolic processes, including lipid uptake, synthesis, and oxidation, regulate CD8+ T cells within tumors. We also assessed the impact of different lipids on CD8+ T-cell-mediated antitumor immunity, with a particular focus on how lipid metabolism affects mitochondrial function in tumor-infiltrating CD8+ T cells. Furthermore, as cancer is a systemic disease, we examined systemic factors linking lipid metabolism to CD8+ T-cell effector function. Finally, we summarize current therapeutic approaches that target lipid metabolism to increase antitumor immunity and enhance immunotherapy. Understanding the molecular and functional interplay between lipid metabolism and CD8+ T cells offers promising therapeutic opportunities for cancer treatment.

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Regulation of CD8+ T cells by lipid metabolism in cancer progression

Tang,

Chen,

Zuo

et al. 2024

Cell Mol Immunol

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Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss

Cited by 1 publication

References 57 publications

Regulation of CD8+ T cells by lipid metabolism in cancer progression

Regulation of CD8+ T cells by lipid metabolism in cancer progression

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