Moderate noise induced cognition impairment of mice and its underlying mechanisms

Cheng, Liang; Wang, Shaohui; Chen, Qi‐Cai; Liao, Xiaomei

doi:10.1016/j.physbeh.2011.06.018

Cited by 125 publications

(104 citation statements)

References 39 publications

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“…In this animal study, we found that moderate noise exposure increased escape latency and decreased the time spent in target quadrant in Morris water maze test (reflecting a damage of spatial learning and memory); and decreased step-through latency and increased the number of mistakes in step-through test (reflecting an injury of memory acquisition of the passive avoidance response, consistent with Cheng's study [28]). Furthermore, we…”

Section: Discussionsupporting

confidence: 89%

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Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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There is increasing evidence that chronic noise stress impairs cognition and induces oxidative stress in the brain. Recently, orientin, a phenolic compound abundant in some fruits, millet, and herbs, has been shown to have antioxidant properties. This study investigated the potential effects of orientin against chronic noiseinduced cognitive decline and its underlying mechanisms. A moderate-intensity noise exposure model was used to investigate the effects of orientin on behavior and biochemical alterations in mice. After 3 weeks of the noise exposure, the mice were treated with orientin (20 mg/kg and 40 mg/kg, oral gavage) for 3 weeks. The chronic noise exposure impaired the learning and memory in mice in the Morris water maze and step-through tests. The noise exposure also decreased exploration and interest in a novel environment in the open field test. The administration of orientin significantly reversed noise-induced alterations in these behavior tests. Moreover, the orientin treatment significantly improved the noise-induced alteration of serum corticosterone and catecholamine levels and oxidative stress in the hippocampus and prefrontal cortex. Furthermore, the orientin treatment ameliorated the noise-induced decrease in brain-derived neurotrophic factor and synapseassociated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus and prefrontal cortex. Thus, orientin exerts protective effects on noise-induced cognitive decline in mice, specifically by improving central oxidative stress, neurotransmission, and increases synapse-associated proteins. Therefore, supplementation with orientin-enriched food or fruit could be beneficial as a preventive strategy for chronic noise-induced cognitive decline. Disciplines Medicine and Health Sciences Publication DetailsWang, S., Yu, Y., Feng, Y., Zou, F., Zhang, X., Huang, J., Zhang, Y., Zheng, X., Huang, X., Zhu, Y. & Liu, Y. (2016). Protective effect of the orientin on noise-induced cognitive impairments in mice. Behavioural Brain Research, 296 290-300.

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Section: Discussionsupporting

confidence: 89%

“…The amplitude of the noise was 80 dB SPL, and the range of noise frequency was from 10 to 10,000 Hz [28]. The noise level was measured with a sound level meter (type WS-1361, Wensn, Dongwan, Guangdong province).…”

Section: Noise Stress Proceduresmentioning

confidence: 99%

Protective effect of the orientin on noise-induced cognitive impairments in mice

Wang

Feng

et al. 2016

Behavioural Brain Research

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“…As Mc2r is the sole receptor for ACTH, this observation may provide insight into how environmental noise exposure may modulate the stress response of the hippocampus. Studies elsewhere have reported that chronic environmental noise exposure is associated with disrupted function of the hippocampus, an extra-auditory structure of the central nervous system, thereby inducing memory deficit and cognition impairment (Cheng et al, 2011;Chengzhi et al, 2011;Manikandan et al, 2006;Uran et al, 2012Uran et al, , 2010Cui et al, 2012Cui et al, , 2013. Indeed, Jáuregui-Huerta et al showed that chronic exposure to environmental noise in the early stages of life produces a long-lasting reduction in cell proliferation in the hippocampus in the neurogenic and non-neurogenic hippocampal regions (Kraus and Canlon, 2012).…”

Section: Discussionmentioning

confidence: 99%

Effects of environmental noise exposure on DNA methylation in the brain and metabolic health

Guo

et al. 2017

Environmental Research

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Environmental noise exposure is associated with adverse effects on human health including hearing loss, heart disease, and changes in stress-related hormone levels. Alteration in DNA methylation in response to environmental exposures is a well-known phenomenon and it is implicated in many human diseases. Understanding how environmental noise exposures affect DNA methylation patterns may help to elucidate the link between noise and adverse effects on health. In this pilot study we examined the effects of environmental noise exposure on DNA methylation of genes related to brain function and investigated whether these changes are related with metabolic health. We exposed four groups of male Wistar rats to moderate intensity noise (70-75dB with 20-4000Hz) at night for three days as short-term exposure, and for three weeks as long-term exposure. Noise exposure was limited to 45dB during the daytime. Control groups were exposed to only 45dB, day and night. We measured DNA methylation in the Bdnf, Comt, Crhr1, Mc2r, and Snca genes in tissue from four brain regions of the rats (hippocampus, frontal lobe, medulla oblongata, and inferior colliculus). Further, we measured blood pressure and body weight after long-term noise exposure. We found that environmental noise exposure is associated with gene-specific DNA methylation changes in specific regions of the brain. Changes in DNA methylation are significantly associated with changes in body weight (between Bdnf DNA methylation and Δ body weight: r=0.59, p=0.018; and between LINE-1 ORF DNA methylation and Δ body weight: =-0.80, p=0.0004). We also observed that noise exposure decreased blood pressure (p=0.038 for SBP, p=0.017 for DBP and p 0. 017 for MAP) and decreased body weight (β=-26g, p=0.008). In conclusion, environmental noise exposures can induce changes in DNA methylation in the brain, which may be associated with adverse effects upon metabolic health through modulation of response to stress-related hormones.

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“…Noise exposure may induce the generation of free radicals and deplete the activities of antioxidant enzymes in plasma and tissues [10,11]. Previous studies have shown that increased oxidative stress is the cause of neuronal degeneration in auditory nuclei as well as the brain regions critical for cognitive functions [6,12,13].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. ARTICLE HISTORY

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Moderate noise induced cognition impairment of mice and its underlying mechanisms

Cited by 125 publications

References 39 publications

Protective effect of the orientin on noise-induced cognitive impairments in mice

Protective effect of the orientin on noise-induced cognitive impairments in mice

Effects of environmental noise exposure on DNA methylation in the brain and metabolic health

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

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