Moderate Strontium Loading Induces Rickets in Rats with Mild Chronic Renal Failure

Abstract

Background/Aims: Renal osteodystrophy and eventually osteoporosis are serious long-term complications in children with end-stage renal disease before and after renal transplantation. Strontium (Sr) salts are used for treatment of osteoporosis in adults. Methods: To evaluate the time-dependent effects of Sr on growth plate morphology and their reversibility, chronic renal failure (CRF) rats received either normal or Sr-loaded drinking water (2 g/l; ±200 mg/kg/day) for periods of 2, 6 and 12 weeks with or without subsequent washout periods of 0, 2, 4 or 8 weeks. Results: While weight gain was not affected by Sr loading, a significant enlargement of the entire growth plate, mainly due to expansion of the hypertrophic zone, was already present after 2 weeks. Sr-loaded animals showed increased osteoid areas and reduced bone formation rates at 2, 6 and 12 weeks compared to controls. This was accompanied by reduced PTH levels and increased serum bone alkaline phosphatase activity. After the washout periods these effects were reversed. In general, the height of the hypertrophic zone was positively correlated with osteoid area and negatively correlated with bone formation rate. Conclusion: Moderate Sr loading in CRF rats results in rapid development of rickets, which is reversible after washout.

Effect of Strontium Ranelate on Bone Metabolism of Elderly Men

“…7,8 The current study participants reached similar levels after 3 months of medication, but studies conducted on animals indicate that high doses of strontium impair bone mineralization in healthy animals, 9 and it has been demonstrated that strontium exerts positive or negative effects, depending on dose, on mineralization and bone metabolism. 10 Thus, it is possible that the sudden increase in strontium in these individuals may have altered their bone metabolism, as reflected in the markers, which could explain the findings. Further studies should be conducted to confirm this possibility.…”

Cell Death Under Conditions of Haptic Contamination of Biological Media by Stable Strontium

“…Показано, что протеинкиназные каскады в различных клеточных культурах способны ингибировать FAS-зависимый апоптоз на уровне активации каспазы-8 [2,4]. В системе in vivo показано, что у крыс с моделированной интоксикацией стронцием (из расчета 2 г/л; ±200 мг/кг/день) наблюдается ингибирования апоптоза хондроцитов [10].…”

Assessment of Health Risk and Elemental Concentrations in Minjingu Vegetables and Soils by Wavelength Dispersive X-ray Fluorescence

“…However the concentration is still higher than the allowable limits of 425 mg/kg of FAO/WHO, therefore the continual consumption of vegetables especially Chinese cabbage which contain greater amount of Fe may lead to hazardous health risks to Minjingu inhabitants. However in required amounts Fe helps in the formation of hemoglobin, oxidation of starch, protein, fat and controls the normal functioning of the central nervous system [64], while the low intake of Fe cause anemia, and tiredness [72].…”