Moderate-Throughput Identification and Comparison of Campylobacter-Infecting Bacteriophages

Abstract

Word Count: 198 Text Word Count: 4875Abstract Campylobacter jejuni is a leading cause of foodborne infection due to its ability to asymptomatically colonize agricultural animals. In addition to its prevalence, Campylobacter is becoming increasingly resistant to the clinical antibiotics, azithromycin and ciprofloxacin. As a result, public health agencies have identified drug resistantCampylobacter as a serious threat to public health and have suggested combating the pathogen at the farm-level by reducing its burden within agricultural animal reservoirs.isolating bacteriophage that infect C. jejuni from various environmental sources. In previous studies, bacteriophage that kill C. jejuni have been isolated from sewage and pig manure; however, the majority have been isolated from chickens, and have been relatively few in number. We postulate this study increases the likelihood of isolating bacteriophage efficacious at combating C. jejuni colonization of agricultural animal hosts at the farm-level or treating infected humans.

Poultry gut health – microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies

“…More recently, bacteriophages capable of ingesting Campylobacter bacteria were reported. The chicken caeca samples used were derived from large poultry farms which did not contain Campylobacter [69].…”