2019
DOI: 10.1152/ajpcell.00104.2019
|View full text |Cite
|
Sign up to set email alerts
|

Moderately elevated extracellular [K+] potentiates submaximal force and power in skeletal muscle via increased [Ca2+]i during contractions

Abstract: The extracellular K+ concentration ([K+]o) increases during physical exercise. We here studied whether moderately elevated [K+]o may increase force and power output during contractions at in vivo-like subtetanic frequencies and whether such potentiation was associated with increased cytosolic free Ca2+ concentration ([Ca2+]i) during contractions. Isolated whole soleus and extensor digitorum longus (EDL) rat muscles were incubated at different levels of [K+]o, and isometric and dynamic contractility were tested… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

7
26
1

Year Published

2021
2021
2024
2024

Publication Types

Select...
5
1

Relationship

1
5

Authors

Journals

citations
Cited by 17 publications
(34 citation statements)
references
References 56 publications
7
26
1
Order By: Relevance
“…With depolarization during infusion of 16 mM K + , there was an initial increase in the Ca 2+ transient from a mean normalized value of 0.81 ± 0.10 to the normalized maximum of 1 (p < .0001 paired t-test, n =12, Fig 3C-E). This increase is similar to what has been reported previously (Quinonez et al, 2010; Pedersen et al, 2019) and occurred despite reduction in AP peak (Fig 3D, see Fig 2D for AP peak plots for the same 12 fibers). As depolarization progressed there was rapid, complete loss of the Ca 2+ transient (Fig 3C-E).…”
Section: Resultssupporting
confidence: 91%
See 4 more Smart Citations
“…With depolarization during infusion of 16 mM K + , there was an initial increase in the Ca 2+ transient from a mean normalized value of 0.81 ± 0.10 to the normalized maximum of 1 (p < .0001 paired t-test, n =12, Fig 3C-E). This increase is similar to what has been reported previously (Quinonez et al, 2010; Pedersen et al, 2019) and occurred despite reduction in AP peak (Fig 3D, see Fig 2D for AP peak plots for the same 12 fibers). As depolarization progressed there was rapid, complete loss of the Ca 2+ transient (Fig 3C-E).…”
Section: Resultssupporting
confidence: 91%
“…Measurement of twitch force in the mouse EDL following elevation of extracellular K + to between 10 and 16 mM yielded results similar to those previously reported. There was an initial increase in force (Fig 1A, n= 3 muscles for each K + concentration) (Cairns et al, 1997; Yensen et al, 2002; Pedersen et al, 2019). The initial increase in force is paralleled by an increase in the Ca 2+ transient, which occurs despite a reduction of AP peak (Quinonez et al, 2010; Pedersen et al, 2019).…”
Section: Resultsmentioning
confidence: 96%
See 3 more Smart Citations