Modern Aspects of Bone Tissue Reparative Regeneration and Analysis of Bone Metabolism Indices

Ryabenko, T. V.; Univercity, Sumy State

doi:10.26693/jmbs05.03.089

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…Both groups of patients are characterized by the presence of disturbances in the ratio between calcium and phosphorus, and in patients with multiple fractures, an increase in the level of alkaline phosphatase was noticed. The detected changes in the mineral metabolism of patients with multiple fractures had a more pronounced and intense nature and were possibly caused by the multiple injuries and the presence in the first days after the injury of a large number of destroyed cells [3,5].…”

Section: Discussionmentioning

confidence: 99%

“…According to the vast majority of authors, clinical and radiological signs of bone fracture healing in patients with multiple injuries of the musculoskeletal system differ from similar parameters in patients with isolated injuries [1,2,3]. As a rule, it takes longer for fusion of fragments in multiple bone fractures compared to monolocal fractures by 1.5-2 times [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Biochemical Signs of the Course of Reparative Osteogenesis in Patients With Fractures of the Lower Extremity

Kalashnikov¹,

Litun²,

Stavinskyi³

et al. 2023

ArveMED

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Background: Some biochemical indicators in patients with disorders of reparative osteogenesis were described in a sufficient number of studies, but the role of factors affecting the metabolism of bone tissue and the ways of their correction are not sufficiently studied .. For effective prediction of the course of reparative osteogenesis in fractures, it is important to identify early markers of impaired consolidation and, accordingly, its pathogenetic correction. Purpose: to determine biochemical indicators of the course of reparative osteogenesis in patients with multiple and monolocal fractures of the bones of the lower limb. Materials and Methods: 44 patients aged 23 to 47 years were examined. To assess the ratio and intensity of the processes of biosynthesis and breakdown of collagen, as the major structural protein of connective tissue, the following indicators were determined in the blood serum of patients: fractions of hydroxyproline, oxyproline, collagenase, cathepsin B, elastase, proteolysis-antielastase inhibitors. In addition, indicators of mineral metabolism were also determined in the blood serum of patients: the content of calcium, phosphorus, alkaline phosphatase activity. Results: A comparative analysis and comparison of the results of the biochemical examination of patients with closed tibial fractures and multiple fractures revealed that already at the beginning of the research, deviations from the norm in the indicators of both mineral and collagen metabolism were observed. Both groups of the patients are characterized by the presence of disturbances in the ratio between calcium and phosphorus, and in patients with multiple fractures - an increase in the level of alkaline phosphatase. The detected changes in the mineral metabolism in patients with multiple fractures had a more pronounced and intense character due to the multiple injuries and presence of a large number of destroyed cells in the first days after the injury. Conclusions: Indicators of the unfavorable course of reparative osteogenesis in patients with bone fractures are a decrease in the content of calcium/phosphorus in blood serum, an increase in the level of free oxyproline and collagenolytic enzymes (collagenase, elastase, cathepsin B). Besides, there is a decrease in the level of proteolysis inhibitors (antielastase, 2-macroglobulin) and a decrease in suspension stability and antioxidant activity, increase in blood fibrinolytic activity. Our findings justify the need for prophylactic drugs that improve reparative osteogenesis soon after the injury (within a month) in patients with multiple fractures in order to activate the processes of reparative regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biochemical Signs of the Course of Reparative Osteogenesis in Patients With Fractures of the Lower Extremity

Kalashnikov¹,

Litun²,

Stavinskyi³

et al. 2023

ArveMED

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Референтные Уровни Карбокситерминального Телопептида Коллагена I Типа В Сыворотке Крови У Жителей Украины Разного Возраста И Пола

Povoroznyuk¹,

Zaverukha²,

Solonenko³

et al. 2021

PJS

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Целью исследования является определение референтного уровня карбокситерминального телопептида коллагена I типа (β-CTX) в сыворотке крови у практически здоровых мужчин и женщин разного возраста, проживающих на территории Украины. Материалы и методы. В исследование были включены 4754 лица в возрасте 20–89 лет (4123 женщины (средний возраст — 59,6 ± 13,6 года) и 631 мужчина (средний возраст — 49,5 ± 16,3 года)). Всех участников распределили по возрасту на 7 групп по десятилетиям (от 20 до 89 лет), и три возрастные группы — 40–49, 50–59 и 60–69 лет — дополнительно разделили на подгруппы по пятилетиям. Также распределение пациентов проводили по геронтологической классификации возраста на 4 группы: молодой возраст — 20–44 года, средний — 45–59 лет, пожилой — 60–74 года и старческий возраст — 75–89 лет. Концентрацию β-CTX определяли в сыворотке крови методом электрохемилюминесцентного иммуноанализа ECLIA на анализаторе Сobas e 411. Результаты. Определено достоверное влияние возраста на вариабельность β-CTX в сыворотке крови: достоверное повышение уровня β-CTX с возрастом у женщин (p < 0,00001) и снижение у мужчин (p < 0,00001). Достоверно более низкий уровень β-CTX обнаружили у женщин в возрасте 20–29 (p < 0,00001) и 30–39 лет (p < 0,00001) по сравнению с мужчинами данного возраста. Однако у женщин 65–69 лет (p = 0,001) выявили достоверно более высокий уровень β-CTX в сыворотке крови по сравнению с мужчинами этой же возрастной группы. Выводы. Обнаружили связь уровня β-CTX в сыворотке крови с возрастом: у мужчин он достоверно снижается с возрастом, у женщин — достоверно повышается. У молодых мужчин в возрасте 20–44 года и женщин в возрасте 65–69 лет концентрация β-CTX была достоверно выше по сравнению с лицами противоположного пола этого же возраста. Полученные нами результаты в отношении уровня β-CTX у практически здоровых лиц разного возраста, проживающих на территории нашей страны, могут быть использованы как референтные показатели для населения Украины.

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Morphological Features of Osteogenic Cells in Young Rats Under Conditions of Chronic Hyperglycemia

Ponyrko¹,

Boomeister²,

Dmitruk³

et al. 2021

VPBM

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Modern Aspects of Bone Tissue Reparative Regeneration and Analysis of Bone Metabolism Indices

Cited by 3 publications

References 23 publications

Biochemical Signs of the Course of Reparative Osteogenesis in Patients With Fractures of the Lower Extremity

Biochemical Signs of the Course of Reparative Osteogenesis in Patients With Fractures of the Lower Extremity

Референтные Уровни Карбокситерминального Телопептида Коллагена I Типа В Сыворотке Крови У Жителей Украины Разного Возраста И Пола

Morphological Features of Osteogenic Cells in Young Rats Under Conditions of Chronic Hyperglycemia

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