Modern conceptions about the pathogenesis of tumor-related epilepsy

Abstract

Tumor-related epilepsy is of interest among the symptomatic epilepsy, that develops in 75% of patients with gliomas low-grade (astrocytomas, oligodendrogliomas — Gr II) and more than 95% of patients with glioneuronal tumors (ganglioglioma — Gr I). Currently, the nature of epileptogenic activity in brain tumors is still controversial, and the search for epileptogenic foci that are part of the tumor zone presents certain difficulties. The authors described the structural changes and metabolism in the tumor and peritumoral zone, immunological status, and molecular genetic features of the tumor, which may explain the pathogenesis of tumor-related epilepsy. In turn, the clarification of the mechanisms of epileptogenesis is a prerequisite for the development of therapeutically effective anticonvulsants, and to improve the strategies of complex treatment of tumors associated with epilepsy.