Modern drug development from traditional medicinal plants using radioligand receptor-binding assays

Misra, Renuka

doi:10.1002/(sici)1098-1128(199811)18:6<383::aid-med3>3.0.co;2-a

Cited by 28 publications

(16 citation statements)

References 17 publications

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“…In addition, chebulinic acid has an inhibition of cancer cell growth and anti-fungal activity [17,18], and corilagin shows antioxidative, antiatherogenic, antihypertensive and anti-inflammatory effects [19][20][21][22]. On the other hand, the ripe fruit of T. chebula is reputed to improve cognitive processes and to promote longevity [23,24].…”

Section: Introductionmentioning

confidence: 99%

Extract from Terminalia chebula Seeds Protect Against Experimental Ischemic Neuronal Damage Via Maintaining SODs and BDNF Levels

et al. 2011

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The fruit of Terminalia chebula Retz has been used as a traditional medicine in Asia and contains tannic acid, chebulagic acid, chebulinic acid and corilagin. Extract from T. chebula seeds (TCE) has various biological functions. We observed the neuroprotective effects of TCE against ischemic damage in the hippocampal C1 region (CA1) of the gerbil that had received oral administrations of TCE (100 mg/kg) once a day for 7 days before the induction of transient cerebral ischemia. In the TCE-treated ischemia group, neuronal neuclei (a marker for neurons)-positive neurons were distinctively abundant (62% of the sham group) in the CA1 4 days after ischemia-reperfusion (I-R) compared to those (12.2% of the sham group) in the vehicle-treated ischemia group. Four days after I-R TCE treatment markedly decreased the activation of astrocytes and microglia in the ischemic CA1 compared with the vehicle-treated ischemia group. In addition, immunoreactivities of Cu, Zn-superoxide dismutase (SOD1), Mn-superoxide dismutase (SOD2) and brain-derived neurotrophic factor (BDNF) in the CA1 of the TCE-treated ischemia group were much higher than those in the vehicle-ischemia group 4 days after I-R. Protein levels of SOD1, SOD2 and BDNF in the TCE-treated ischemia group were also much higher than those in the vehicle-ischemia group 4 days after I-R. These results indicate that the repeated supplement of TCE protected neurons from ischemic damage induced by transient cerebral ischemia by maintaining SODs and BDNF levels as well as decreasing glial activation.

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Section: Introductionmentioning

confidence: 99%

Extract from Terminalia chebula Seeds Protect Against Experimental Ischemic Neuronal Damage Via Maintaining SODs and BDNF Levels

et al. 2011

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“…Ayurveda, one of the major traditional forms of medicine practiced in India, has borne out many useful drug leads for chronic diseases [6]. The extracts from the root of the medicinal plant Withania somnifera (Ashwagandha in Sanskrit) have been used in particular for the treatment of disorders of the uterus, menstrual cycle and arthritis [7,8].…”

Section: Introductionmentioning

confidence: 99%

Withaferin A is a potent inhibitor of angiogenesis

et al. 2004

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The medicinal plant Withania somnifera is widely researched for its anti-inflammatory, cardioactive and central nervous system effects. In Ayurveda , the major Traditional Indian medicine system, extracts from W. somnifera are distinctively employed for the treatment of arthritis and menstrual disorders. Because these conditions involve angiogenic processes we hypothesized that the W. somnifera extracts might contain angiogenesis inhibitors. We employed an endothelial cell-sprouting assay to monitor the purification of substances from W. somnifera root extracts and isolated as the active principle the previously known natural product withaferin A. We show that withaferin A inhibits human umbilical vein endothelial cell (HUVEC) sprouting in three-dimensional collagen-I matrix at doses which are relevant to NF-kappa B-inhibitory activity. Withaferin A inhibits cell proliferation in HUVECs (IC50 =12 nM) at doses that are significantly lower than those required for tumor cell lines through a process associated with inhibition of cyclin D1 expression. We propose that the inhibition of NF-kappa B by withaferin A in HUVECs occurs by interference with the ubiquitin-mediated proteasome pathway as suggested by the increased levels of poly-ubiquitinated proteins. Finally, withaferin A is shown to exert potent anti-angiogenic activity in vivo at doses that are 500-fold lower than those previously reported to exert anti-tumor activity in vivo. In conclusion, our findings identify a novel mode of action of withaferin A, which highlights the potential use of this natural product for cancer treatment or prevention.

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“…It is recommended for improving memory and mind and also treatment of amnesia. The ripe fruit of T. chebula is regarded as a promoter of intellect and memory, and is believed to prolong life (Manyam, 1999;Misra, 1998). The ripe fruit is reputed to retard the ageing process and to improve cognitive processes and so, has benefits in AD (Manyam, 1999).…”

Section: Terminallia Chebulamentioning

confidence: 99%

Medicinal herbs in Iranian traditional medicine for learning and memory

Shojaii¹,

Ghods²,

Fard³

2016

Afr. J. Trad. Compl. Alt. Med.

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Background: There are some factors such as age, stress and emotions that may lead to impaired learning, memory loss, amnesia, and dementia or threats like Schizophrenia and Alzheimer's disease (AD). Traditional Iranian medicine (TIM) recommended some herbs and herbal preparations for treatment or prevention of CNS problems. In this study, the scientific evidences related to effectiveness of TIM herbal medicine on memory and learning will be reviewed. Materials and Methods:The scientific evidences of the plant efficacy were searched in electronic databases including Pub Med, Scopus, SID, Science Direct, and Google Scholar by keywords like memory, Alzheimer, amnesia, learning and scientific plant names from 1969 to 2014. Results: The finding of this study confirmed effectiveness of some of TIM medicinal plants on enhancing memory and learning or in treatment or prevention of amnesia and AD. Some of TIM plants like Melissa officinalis, Crocus sativus and Nigella sativa showed improving effect on memory in clinical trials. In some cases, the active principles responsible for efficacy of these plants on memory were also determined. Conclusion: Most of the studies on TIM plants were designed in animal models and a few herbs were evaluated in clinical trials on AD. Also, for some of the herbal medicine used in TIM, there are no or not enough studies to confirm their effectiveness on memory and learning. Therefore, further experimental and clinical studies are necessary to evaluate the effectiveness of these plants on memory and AD and also to determine the active components of them.

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Modern drug development from traditional medicinal plants using radioligand receptor-binding assays

Cited by 28 publications

References 17 publications

Extract from Terminalia chebula Seeds Protect Against Experimental Ischemic Neuronal Damage Via Maintaining SODs and BDNF Levels

Extract from Terminalia chebula Seeds Protect Against Experimental Ischemic Neuronal Damage Via Maintaining SODs and BDNF Levels

Withaferin A is a potent inhibitor of angiogenesis

Medicinal herbs in Iranian traditional medicine for learning and memory

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