Modern Drug Discovery and Development in the Area of Leishmaniasis

Goyal, Neena; Patel, Manas Ranjan; Batra, Sanjay

doi:10.1007/978-981-15-8002-4_5

Cited by 3 publications

(1 citation statement)

References 148 publications

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“…Among the four pyrazolopyrimidine isomers (see Scheme 1), pyrazolo [1,5-c]pyrimidines are the least studied in terms of synthesis, structure or biological activities (Elnagdi et al, 1987). Chemotypes based on pyrazolo [1,5-c]pyrimidines have been shown to possess antileishmanial activity (Atta et al, 2017;Goyal et al, 2021) and antiviral activity against herpesviruses (Gudmundsson et al, 2009). Pyrazolotriazolo-[1,5-c]pyrimidine derivatives have been reported as adenosine receptor antagonists (Federico et al, 2012;Baraldi et al, 2012;Redenti et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Crystal structure and self-assembly on graphite of a pyrazolo[1,5-c]pyrimidine derivative

Trivedi¹,

Gupta²,

Mishra³

et al. 2021

Acta Crystallogr C

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The crystal structure of the heterocyclic compound 2-(4-methoxyphenyl)-7-phenylpyrazolo[1,5-c]pyrimidine, C19H15N3O, has been determined and its self-assembly on the surface of graphite has been examined using atomic force microscopy (AFM). The title compound crystallized in the monoclinic space group P21/c, with two independent molecules in the asymmetric unit. The packing of the L-shaped molecules in the crystal is governed by arene interactions, in the absence of any conventional hydrogen-bonding interactions. The packing arrangement reveals four types of dimeric motifs stabilized by π–π and C—H...π interactions. At low coverage, molecules assemble into long needle-like islands on the graphite surface. High-resolution AFM images reveal that the molecules interact through weak noncovalent interactions between the aromatic H atoms and the methoxy O atoms.

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