Modern markers for evaluating bone disease in multiple myeloma (Review)

Pop, Vlad; Pârvu, Andrada; Crăciun, Alexandra; Fărcăş, Anca Daniela; Tomoaia, Gheorghe; Bojan, Anca

doi:10.3892/etm.2021.10764

Cited by 10 publications

(7 citation statements)

References 45 publications

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“…It is important to note that lower serum ratio of vitamin D to β-CTX not only predicts OS but also predicts PFS in patients with NDMM, which is also in line with the high-risk clinical characteristics and cytogenetics. The serum levels of β-CTX is sensitive to predicting subclinical bone disease before the onset of manifested lytic lesions, which is capable of detecting the degree of bone resorption in MM ( 32 ). Our findings highlight the importance of β-CTX levels in the relationship between vitamin D deficiency and clinical prognosis in patients with NDMM.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis

Bao¹,

Wang²,

Lu³

et al. 2023

Front. Endocrinol.

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PurposeVitamin D deficiency is frequent in patients with multiple myeloma (MM), however, its prognostic relevance in MM was rather inconclusive. We first investigated the association of vitamin D deficiency with abnormal bone and lipid metabolism in newly diagnosed multiple myeloma (NDMM), and next assessed the impact of serum ratio of vitamin D to carboxy-terminal telopeptide of type I collagen (β-CTX) on progression-free survival (PFS) and overall free survival (OS) in patients with NDMM.MethodsThe data of 431 consecutive patients with NDMM at Beijing Jishuitan Hospital from September 2013 to December 2022 were collected and retrospectively reviewed through our electronic medical record system. The measurement of 25-hydroxyvitamin D in the blood is an indicator of an individual’s overall vitamin D status.ResultsThe serum levels of vitamin D were negatively correlated with β-CTX in NDMM patients. Of note, positive correlation between vitamin D and cholesterol levels in the serum was found in this study. The cohort (n = 431) was divided into two groups based on the serum ratio of vitamin D to β-CTX. Compared to the group with a higher vitamin D to β-CTX ratio, the group with a lower vitamin D to β-CTX ratio (n = 257, 60%) exhibited hypocholesterolemia, inferior PFS and OS, along with increased cases of ISS stage-III and R-ISS stage-III, a higher number of plasma cells in the bone marrow, and elevated serum calcium levels. Consistent with this, multivariate analysis confirmed that the vitamin D to β-CTX ratio was an independent unfavorable indicator for survival in NDMM patients.ConclusionOur data demonstrated the ratio of vitamin D to β-CTX in the serum is a unique biomarker for NDMM patients to identify the high-risk cases with poor prognosis, which is superior to vitamin D itself for predicting PFS and OS in NDMM. Also, it is worth mentioning that our data on the connection between vitamin D deficiency and hypocholesterolemia might help clarify novel mechanistic aspects of myeloma development.

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Section: Discussionmentioning

confidence: 99%

Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis

Bao¹,

Wang²,

Lu³

et al. 2023

Front. Endocrinol.

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“…This is attributed to the production of osteoclast-activating factors by myeloma cells, [ 8 ] which subsequently stimulates osteoclast activity. [ 9 ] As a result, bone disintegration and destruction occur. Potential outcomes include bone pain, bone deformation, and pathological fracture.…”

Section: Clinical Featuresmentioning

confidence: 99%

New diagnostic strategy for multiple myeloma: A review

Xu,

2023

Medicine

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Multiple myeloma (MM) is the second most prevalent hematological malignancy and is distinguished by the aberrant proliferation of monoclonal plasma cells inside the bone marrow and production of M-protein. This condition frequently results in bone deterioration, acute kidney damage, anemia, and hypercalcemia. However, the clinical manifestations and accompanying symptoms of MM vary and may change as the condition evolves. Therefore, diagnosis of MM is difficult. At present, the confirmation of MM diagnosis necessitates the use of bone marrow biopsy, a procedure that is both invasive and challenging for assessing dynamic alterations in the disease. The integration of laboratory testing technologies with imaging technology has the potential to enhance the diagnostic effectiveness and provide a thorough evaluation of disease progression and prognosis in patients with MM. All the examination methods have advantages and disadvantages. Therefore, diagnosis is determined by the application of clinical characteristics, serological tests, and imaging investigations.

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“…The patients' age median in Brazil is 63 years old, varying from 18 to 100, according to the Oncology Observatory 3 . In turn, in Europe the age median at the time of diagnosis is 72 years old, indicating that MM is an aged people's disease 4 .…”

Section: Rbfhssmentioning

confidence: 99%

Utilização de medicamentos que induzem osteoporose ou fratura em idosos com mieloma múltiplo: estudo transversal

Rosa¹,

Pádua²,

Machado³

et al. 2023

Rev Bras Farm Hosp Serv Saude

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Objetivo: descrever a frequência de utilização de medicamentos que induzem osteoporose ou fratura (MOF) em idosos com mieloma múltiplo (MM) e avaliar os fatores associados. Métodos: estudo transversal, desenvolvido com pacientes em tratamento de MM em três cenários: um hospital público de ensino, um serviço privado ambulatorial de onco-hematologia um hospital público, referência em oncologia. Os dados foram coletados entre abril de 2019 a março de 2020 por meio de entrevistas face a face e revisão de prontuários dos pacientes. A variável dependente foi o uso de MOF, que foram identificados em estudos previamente realizados a partir de duas bases de dados de farmacovigilância: Vigibase da Organização Mundial de Saúde e na Japanese Adverse Drug Event Report (JADER), que calcularam o reporting odds ratio (ROR) de osteoporose ou fratura para os medicamentos. Os medicamentos foram classificados segundo o nível 4 da sistemática da Anatomical Therapeutic Chemistry- ATC. Os fatores associados ao uso de MOF em pacientes com MM incluídos no estudo foram determinados por regressão logística múltipla. Resultados: foram incluídos 153 idosos (≥ 60 anos), com mediana de idade de 70,9 anos, predomínio do sexo feminino (54,2%). A maioria dos idosos (56,9%) foi atendida no serviço de saúde privado. A comorbidade mais encontrada foi hipertensão arterial (67,3%) seguida por diabetes mellitus (28,8%). Identificou- se que 73,2% dos idosos faziam uso de pelo menos um MOF. Os MOF mais frequentes foram os inibidores da bomba de prótons (IBPs) (29,2%), sulfonamidas (13,9%) seguidos por medicamentos relacionados a benzoadiazepinicos (11,9%) e outros opioides (10,4%). Os idosos que utilizaram MOF apresentaram as seguintes características: idade até 70 anos, sexo feminino, renda de até três salários, escolaridade alta (Ensino médio ou superior), multimorbidade, hipertensão arterial e polifarmácia. Na análise multivariada, obteve-se associação independente e positive entre uso de MOF e polifarmácia, MOF e escolaridade alta. Conclusão: a frequência de utilização de MOF pelos idosos estudados foi elevada e associada de forma positiva e independente com polifarmácia e alta escolaridade. As classes ATC dos MOF com maior frequência de utilização foram: IBP, diuréticos de alça (sulfonamidas), medicamentos relacionados a benzodiazepinicos e opioides.

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Modern markers for evaluating bone disease in multiple myeloma (Review)

Cited by 10 publications

References 45 publications

Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis

Vitamin D deficiency linked to abnormal bone and lipid metabolism predicts high-risk multiple myeloma with poorer prognosis

New diagnostic strategy for multiple myeloma: A review

Utilização de medicamentos que induzem osteoporose ou fratura em idosos com mieloma múltiplo: estudo transversal

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