Modern tactics of treatment of malignant glyom of the brain and the case of the complete answer of the tumor on the background of the long-term reception of bevacizumab

Муфазалов, Ф. Ф.; Аббасова, Р. Р.; Муфазалова, Н. А.; Гончарова, О. В.; Сафина, Л. Х.; Муфазалова, Л. Ф.

doi:10.18027/2224-5057-2017-2-33-39

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Злокачественные глиомы являются третьей по частоте причиной смерти от новообразований в группе молодых людей в возрасте до 35 лет. Несмотря на очевидные успехи нейроонкологии последних лет в области молекулярно-генетических исследований, применение всех возможных методов элиминации злокачественных глиом, значительный прогресс в лечении данной тяжелой патологии не достигнут [1][2][3][4][5]. Основным критерием, ограничивающим эффективность применения метода лечения глиом, являются биологическая природа опухоли и особенности головного мозга.…”

Section: резюме _____________________________________________________...unclassified

“…2, верхний ряд), [31]. После того как опухоль начинает снова расти, пациенты могут получить дополнительное лечение, включая повторную резекцию опухоли, бевацизумаб (антитела против VEGF), другую химиотерапию или дополнительную лучевую терапию, ориентированную на зону роста опухоли [5]. Тем не менее такие меры незначительно увеличивают выживаемость.…”

Section: процесс рецидивирования глиомыunclassified

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Molecular Genetic Aspects of Gliomas Development and Progression: A Literature Review

Федулов¹,

Боровский²,

Давидян³

et al. 2022

Неврология И Нейрохирургия. Восточная Европа

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Злокачественные глиомы – наиболее распространенные и опасные первично-мозговые опухоли у взрослых. Причиной неблагоприятного исхода у пациентов становится рецидивирование опухоли, которая приобретает способность уклоняться от терапевтического воздействия. Актуально формирование новой стратегии разработки методов лечения, направленных именно на резистентные клетки. Недавние геномные исследования раскрыли сложнуюгетерогенность глиом и позволили по-новому взглянуть на геномный ландшафт опухолевых клеток, которые выживают на фоне проводимого лечения и инициируют рецидив опухоли. Резистентные клетки также обладают свойствами стволовых клеток; по этой причине предложено называть их рецидивинициирующими стволовыми клетками (РИСК). Генетические изменения и перепрограммирование генома лежат в основе врожденной адаптивной резистентности РИСК. В целях предотвращения рецидива опухоли терапевтическое воздействие необходимо направить в том числе на данную субпопуляцию клеток. Malignant gliomas are the most commonand dangerous primary brain tumors in adults.The cause of unfavorable outcomes in patients is the recurrence of the tumor, which acquires the ability to evade therapeutic effects. A new strategy for developing therapies targeting resistant cells is relevant. Recent genomic studies revealed a complex heterogeneity of gliomas and provided new insights into the genomic landscape of tumor cells surviving existing treatments and initiating tumor recurrence. Resistant cells also possess properties of stem cells; for this reason, it has been proposed to name them recurrence-initiating stem-like cancer (RISC). Genetic changes and genome reprogramming underlie the innate adaptive resistance of RISС cells. In order to prevent tumor recurrence, the therapeutic effect should be aimed, among other things, toward this cell subpopulation.

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Section: резюме _____________________________________________________...unclassified

Section: процесс рецидивирования глиомыunclassified

Molecular Genetic Aspects of Gliomas Development and Progression: A Literature Review

Федулов¹,

Боровский²,

Давидян³

et al. 2022

Неврология И Нейрохирургия. Восточная Европа

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Diagnosis and treatment of subtentorial brain tumors in children at the beginning of the XXI century

Ngankam,

Dolgopolov,

Chichanovskaya

et al. 2023

Nevrol. ž. im. L.O. Badalâna

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Cerebral tumors are among the most menacing pathologies occurring in children. Of all the cerebral tumors, posterior cranial fossa tumors have been most widespread in children. The review of literature provides a detailed description of clinical pattern. The sources related about earlier occurrence of non-focal symptoms, rather than focal signs: lack of energy, nausea, vomiting and headache. The authors provided detailed description of cerebellum damage in case of tumors, and split the symptoms of the hemisphere and vermis injuries as ataxy and typical cerebellar gait are common to spot the malignant process in the vermis, whereas dyssynergia and hypomyotonia occur in case of hemisphere damage. The clinical picture of hydrocephalus in tumor pathology of posterior cranial fossa is discussed: rapidly growing child head circumference, separation of cranial sutures, bulging of fontanelle, child restless behavior, and other signs. The need for CT and MRI was substantiated as the most important diagnostic techniques; the benefits of each were also stated. Discussion was given to the clinical pattern of hydrocephalus in tumor pathology of the posterior cranial fossa, and the authors put special emphasis on the significance of presurgical correction of hydrocephalus. The authors mentioned the use of a neuronavigation system during surgical intervention and characterized the major accesses (access via the median aperture, transvermial, telovelar access) and methods of craniotomy, indications for resection and osteoplastic trepanation. This article discussed the basic principles of radio and chemotherapy used to achieve a sustained remission, approximate treatment patterns for various posterior cranial fossa tumors are described. In addition, the authors mentioned the need for MRI with contrast agent each 3 months, and subsequent visits to the specialist in oncology.

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Study of the Histological Features of the Stroma of High-Grade Gliomas Depending on the Status of the Mutation in the IDH1 Gene

Darya,

Ksenia,

Elizaveta

et al. 2024

IgMin Res

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High-grade gliomas are known for their aggressive nature and resistance to therapy. One characteristic feature of these tumors is the lack of a clear border between the tumor and normal brain tissue. Previous studies have shown that as gliomas dedifferentiate, the extracellular matrix (ECM) undergoes changes in its composition and architecture. This is due to increased production and overexpression of ECM components such as hyaluronic acid, fibulin-3, and collagen. However, it is not yet known what specific changes occur in the stroma of high-grade gliomas depending on the v in the IDH1 gene. In our study, we examined tumor tissue samples from 31 patients, 10 of whom had verified IDH-mutant astrocytoma (grade 4) and 21 had IDH-wildtype glioblastoma (grade 4). The presence or absence of mutations in the IDH1/2 genes was determined in all patients using immunohistochemistry (IHC) and polymerase chain reaction (PCR). To assess stromal changes, we used histochemical staining with Alcian blue and Mallory trichrome. Our results showed significant differences between the two groups according to Student’s t-test (p < 0.05) for all stainings. The presence of mucus formation, collagen formation, and expression of vimentin by tumor cells in the stroma of IDH-wildtype grade 4 glioblastoma indicates an active epithelial-mesenchymal transition and changes in the extracellular matrix. These findings may explain the more unfavorable prognosis in patients with glioblastomas and could potentially serve as a therapeutic target in the complex treatment of malignant gliomas.

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Modern tactics of treatment of malignant glyom of the brain and the case of the complete answer of the tumor on the background of the long-term reception of bevacizumab

Cited by 3 publications

References 22 publications

Molecular Genetic Aspects of Gliomas Development and Progression: A Literature Review

Molecular Genetic Aspects of Gliomas Development and Progression: A Literature Review

Diagnosis and treatment of subtentorial brain tumors in children at the beginning of the XXI century

Study of the Histological Features of the Stroma of High-Grade Gliomas Depending on the Status of the Mutation in the IDH1 Gene

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