modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

Abstract

Antibiotics have saved countless lives and continue to be the backbone for treating bacterial infections. β-Lactam antibiotics have been successfully introduced as antibacterial agents in the early 1950s. They are still the most popular drugs for treating bacterial infections of many diseases. As a result, the biological applications of these compounds and their complexes have attracted remarkable of metal ions (Cu (II), Co (II), Ni (II), Zn (II), Eu (III), and Tb (III) with amoxicillin(H 2 Ax) (Ax) and some selected amino acids (L-glycine (Gly), L-methionine (Met), L-asparagine (Asn), L-histidine (His) and DL-alanine (Ala) have been investigated potentiometrically, 0.1M KNO 3 ionic strength, in an aqueous medium at 20 o C. The dissociation constants and formation constants of ligands and their metal complexes were calculated from potentiometric data using the Irriving-Rossotti method. The acid-base characteristics of ligands have been examined and discussed. It was found that complexes It has been found that amoxicillin does as a primary ligand for the interaction of metal ions in the presence of glycine, alanine, or histidine amino acids. On the other hand, in the case of methionine or asparagine, amoxicillin acts as a secondary ligand. Stabilities of ternary complexes to metal ions were in the following order: Zn(II)< Cu(II) > Ni(II) >Co(II) for transition metal ions and Eu(III) > Tb(III) for lanthanide metal ions. The concentration distribution curves of the binary and ternary complexes formed in the solution were evaluated as a function of pH using the HYSS program.

Thermodynamic parameters of phenylglycine interaction with UO22+, La3+ and Zr4+

“…Several authors have been curious about investigating the communication between transitional metal ions and amino acids due to their relevance at the present time, the importance of amino acids as the building blocks of protein molecules and hormones, and the fact that transitional metal ions are present in all plant and animal organisms [ 1 – 8 ]. As a result, this research is a crucial step in the overall framework of our laboratory [ 9 – 12 ], in this study, the complexation mechanisms between phenylglycine and various transition metal ions (UO 2 2+ , La 3+ and Zr 4+ ) are examined in terms of a unique thermodynamic technique.…”

New Cortisol Schiff Base Synthesis and Some Complexes: Anti-inflammatory studies in silico and in vitro

“…Orabi et al [9] published ternary complexes of amoxicillin with amino acids and metal ions that were studied potentiometrically to determine their stability constants, which could provide information about the ability of ligands to form complexes and the activities of the formed complexes, used for biological applications. Ternary complexes were formed in an associational manner.…”