Modern view on the pathogenesis of proliferative diseases of the uterus

Bazhenova, L. G.; Shramko, S. V.; Sabantsev, M. A.; Gulyaeva, L. F.

doi:10.17116/rosakush20181806131

Cited by 2 publications

(1 citation statement)

References 67 publications

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“…Traditionally, the leading role in the pathogenesis of endometrial hyperplasia in patients of reproductive age is attributed to the increased estrogen concentrations arising from the absence or insufficient anti-estrogenic effect of progesterone [3]. The results of scientific researches of the last years testify in favor of infectious-inflammatory concept of developing the hyperplastic processes of genitals [4,5,6]. Chronic inflammatory diseases of the genitals are the basis for the occurrence of infertility, disorders of menstrual function, hyperplastic uterine processes and endometrium [7,8].…”

Section: Introductionmentioning

confidence: 99%

Immunoglobulin Indicators to Viruses Cytomegal and Genital Herpes in the Blood Serum of Women With Non-Atipical Endometrial Hyperprolifetative Pathology

et al. 2020

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The aim of the study was to analyze the level of Ig M- and Ig G-antibody (Ab) for cytomegalovirus (CMV) and herpes simplex virus type 2 (HSV-2) in serum of women with non-atypical endometrial hyperproliferative pathology. Materials and methods: The analysis of immunoglobulin indices to CMV and HSV-2 in serum of women with non-atypical endometrial hyperproliferative pathology. In women with uterine body polyps the presence of CMV in the uterine cavity was found in 54.8% of cases, in women with non-atypical endometrial hyperplasia in 38.3% of cases. The levels of Ig G-Ab and Ig M-Ab to CMV in serum have a clear dependence on the degree of antigen expression in endometrial tissue. HSV-2 antigens were determined in 22.58 ± 5.31% of women with uterine body polyps and in 8.33 ± 3.57% of patients with non-atypical endometrial hyperplasia while increasing serum specific antibodies to HSV-2. Results: The results indicate that there is a clear link between viral infection of hyperproliferatively altered endometrium and the determination of positive immunoglobulin levels in peripheral blood, which may be a reliable marker of chronic persistent viral infection in a woman’s body. Conclusions: In women with uterine body polyps, the presence of CMV in the uterine cavity was found in 54.84 ± 6.32% of cases, in women with non-atypical endometrial hyperplasia in 38.33 ± 6.28% of cases. The levels of Ig G-Ab and and Ig M-Ab to CMV in serum have a clear dependence on the degree of antigen expression in endometrial tissue. HSV-2 antigens were determined in 22.58 ± 5.31% of women with uterine body polyps and in 8.33 ± 3.57% of patients with non-atypical endometrial hyperplasia while increasing serum specific antibodies to HSV-2. The results indicate that there is a clear link between viral infection of the target tissue (hyperproliferatively altered endometrium) and the determination of a positive level of peripheral blood immunoglobulin, which may be a reliable marker of chronic persistent viral infection in a woman.

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Section: Introductionmentioning

confidence: 99%

Immunoglobulin Indicators to Viruses Cytomegal and Genital Herpes in the Blood Serum of Women With Non-Atipical Endometrial Hyperprolifetative Pathology

et al. 2020

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Features of the content of homocysteine and thyroid hormones in pregnant women with uterine myoma

Khamidullina

Davidyan

2020

Medicinskij sovet

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The purpose and objectives of the study is to assess the effect of hyperhomocysteinemia on the first trimester of gestation in women with uterine myoma. Relevance. Biochemical and hormonal changes that occur in the myometrium and the body of a woman as a whole, without preventing the onset of pregnancy, can have a significant effect on the formation of the chorion and the clinical course of the gestational process, provoking complications such as miscarriage. Material and research methods. To achieve this goal, we examined 182 pregnant women, of which the main group was 98 pregnant women with a verified diagnosis of uterine fibroids, which took place before gestation, but did not prevent pregnancy. The comparison group included 84 pregnant women without anamnestic indications of gynecological pathology and signs of fetoplacental insufficiency. Results. We made an attempt to highlight the features of the content of homocysteine and thyroid hormones in pregnant women with uterine myoma and the influence of these indicators on the onset of gestation. Considering the results obtained, we indicate that pregnant women with uterine fibroids and without a tumor had significant differences in individual values. Conclusions. In women with benign tumors of the uterus that are pregnant, the most common conditions in the first trimester are mild anemia and genital tract bleeding. Half of the observed pregnant women with uterine myoma have hyperhomocysteinemia and, in some of them, subclinical hypothyroidism. This must be considered when preparing for the pregnancy of these women.

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Modern view on the pathogenesis of proliferative diseases of the uterus

Cited by 2 publications

References 67 publications

Immunoglobulin Indicators to Viruses Cytomegal and Genital Herpes in the Blood Serum of Women With Non-Atipical Endometrial Hyperprolifetative Pathology

Immunoglobulin Indicators to Viruses Cytomegal and Genital Herpes in the Blood Serum of Women With Non-Atipical Endometrial Hyperprolifetative Pathology

Features of the content of homocysteine and thyroid hormones in pregnant women with uterine myoma

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