Modern Views on the Problem of Stem Cells and Potentialities of Their Use in Medicine

Mechanisms of Therapeutic Effects of Granulocytic Colony-Stimulating Factor in Experimental Diabetes Mellitus

“…The study of mechanisms of regeneration of "deep" reserve associated with stem cells [2,4,9] under the effect of G-CSF revealed the following phenomena. Course treatment with the preparation led to considerable mobilization of parental cells accompanied by a decrease in the number of committed mesenchymal precursors in the bone marrow (day 21; Table).…”

“…We observed a considerable increase in the number of parenchymal stem cells (to 154.0% compared to the control on day 11) and stromal precursors (to 143.0% on day 15) in the pancreas (Table 1). Taking into account the results of histological study demonstrating the absence of sclerotic processes after treatment with G-CSF, the increase in the content of CFU-F in the target organ can be considered as a result of intensification of restitution processes, in particular, recovery of the microenvironment regulating functional activity of organ-specific cells in situ [2,4].…”

“…Unfortunately, there are no radical methods for the treatment of this condition [1,8]. Recent advances in cell technologies open the possibilities for the development of new approaches to the treatment of this pathology [2]. Pharmacological stimulation of the functions of endogenous progenitor elements based on simulation of natural regulatory functional systems is the most physiological method of regenerative medicine [4,5,9].…”

Mechanism of mobilization of mesenchymal stem cell under the effect of granulocyte colony-stimulating factor

“…from the bone marrow, into circulation [1,5]. However, the mechanisms underlying enhanced migration of MSC under the effect of G-CSF are not quite understood.…”

Multipotent stem and progenitor cells of the olfactory epithelium

“…Adult mammalian brain (including human brain) contains neural stem cells in the subependymal zone of the lateral ventricles and in the subgranular zone of the hippocampal fascia dentata [17,32,33,[38][39][40]63,67,95,102,120]. Due to the capacity to differentiate into neurons and glia, transplantation of neural stem and progenitor cells opens new vistas for the treatment of many diseases and injuries of human central nervous system [1,2,4,6,24,26,31,82,84,98,103,105,107,109,117,121]. However, the use of human fetal stem cells for this purpose is associated with many ethical and religious problems [49,85], while transplantation of neural stem cells located in structures of mature brain is in fact impossible, because these cells can be obtained only by invasive neurosurgical methods.…”