Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines

Valsamakis, Georgios; McTernan, P. G.; Chetty, R.; Al-Daghri, Nasser M.; Field, Annmarie; Hanif, Wasim; Barnett, Anthony; Kumar, Sudhesh

doi:10.1016/j.metabol.2003.11.022

Cited by 174 publications

(136 citation statements)

References 28 publications

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“…34 Medical treatment with sibutramine or orlistat for 6 months achieved a reduction in CRP despite less weight loss (2-5.4%). 39 A 3-month cardiac rehabilitation and exercise training programme for coronary heart disease sufferers resulted in a reduction in cardiovascular risk factors and CRP levels regardless of statin therapy or weight loss, 40 and a similar programme for 18 months, involving overweight or obese subjects above 60 y of age, showed a decrease in CRP, IL-6 and TNF-a levels. 36 Likewise, surgically induced weight loss through gastric banding 4,41 lowered CRP to within the normal range.…”

Section: Discussionmentioning

confidence: 99%

CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects

et al. 2005

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OBJECTIVE: Obesity is frequently associated with insulin resistance, dyslipidemia, hypertension and an increased risk of cardiovascular disease, reflected in elevated markers of inflammation, in particular C-reactive protein (CRP). To what extent the insulin resistance or the obesity per se contributes to increased CRP levels is unclear. In morbidly obese patients, gastric bypass surgery causes marked changes in body weight and improves metabolism, thereby providing informative material for studies on the regulation of inflammatory markers. DESIGN: Prospective, surgical intervention study of inflammatory markers in morbidly obese subjects. SUBJECTS: In total, 66 obese subjects with mean age 39 y and mean body mass index (BMI) 45 kg/m 2 were studied prior to and 6 and 12 months following Roux-en-Y gastric bypass (RYGBP) surgery. MEASUREMENTS: Serum concentrations of high sensitivity CRP, serum amyloid A (SAA) and interleukin-6 (IL-6), as well as markers of glucose and lipid metabolism. RESULTS: Prior to surgery, CRP levels were elevated compared to the reference range of healthy, normal-weight subjects. CRP correlated with insulin sensitivity, as reflected by the homeostatic model assessment (HOMA) index, but not BMI, when corrected for age and gender. Surgery reduced BMI from 45 to 31 kg/m 2 and lowered CRP, SAA and IL-6 levels by 82, 57 and 50%, respectively, at 12 months. The reduction in CRP was inversely related to HOMA at baseline independently of the change in body weight (r ¼ À0.36, P ¼ 0.005). At 12 months, 140 and 40% reductions in CRP were seen in subjects with HOMA o 4 (insulin sensitive) and HOMA49 (insulin resistant) despite similar reductions in BMI. Reductions in SAA and IL-6 tended to parallel the changes in CRP, but were less informative. CONCLUSION: In morbidly obese subjects, gastric bypass surgery lowers energy intake, reduces inflammatory markers and improves insulin sensitivity. Despite a marked reduction in body weight, only a small effect on CRP levels was seen in insulinresistant patients, indicating that flexibility of circulating CRP levels is primarily dependent upon insulin sensitivity rather than energy supply.

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Section: Discussionmentioning

confidence: 99%

CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects

et al. 2005

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“…Studies on weight reduction show contradictory findings. Some investigators observed a decrease in serum resistin during weight loss 5,10 or an increase during weight gain, 32 while others reported no changes in serum resistin. 33,34 In the present study, serum resistin was positively correlated to serum fructosamines and HOMA-SI.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Recent studies do not suggest a major role of resistin in the regulation of glucose metabolism and insulin resistance in humans. Circulating resistin was reported to be elevated in human obesity in some, [3][4][5] but not in all studies. [6][7][8] Positive correlations of circulating resistin and insulin resistance 9,10 could not be confirmed in other studies.…”

Section: Introductionmentioning

confidence: 95%

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

et al. 2006

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Objective: Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear. Design: Cross-sectional study for comparisons of lean and obese subjects, and subsequent longitudinal 4-month weight loss intervention study in obese subjects. Subjects: Healthy subjects, lean (n ¼ 20, BMIo25) and overweight (n ¼ 43, BMIX25). Measurements: Serum resistin, body weight, body fat, waist-to-hip ratio, as well as markers of insulin resistance and lipid metabolism at baseline and after 4 months of intervention. Results: Serum resistin was positively correlated to HOMA-IR (partial r ¼ 0.288; P ¼ 0.055), serum fructosamines (partial r ¼ 0.280; P ¼ 0.062), serum NEFA (partial r ¼ 0.276; P ¼ 0.066) and negatively to age (partial r ¼ À0.349; P ¼ 0.019) and serum apolipoprotein A-1 (partial r ¼ À0.363; P ¼ 0.014). During the intervention, serum resistin increased significantly (Po0.001). The increase was inversely related to changes in waist-to-hip ratio (P ¼ 0.025) and positively to serum apolipoprotein B (P ¼ 0.011). In males only, the increase in resistin during weight loss was predicted by total serum cholesterol at baseline (r ¼ 0.703, P ¼ 0.007). No relation was observed between changes in resistin and changes in HOMA-IR. Conclusion: The present study indicates an association between serum resistin and markers of abdominal fat distribution as well as the regulation of lipid metabolism. However, human resistin is unlikely to play an independent role in the regulation of glucose metabolism.

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“…Despite the great number of cross-sectional studies, there are only few longitudinal studies in adulthood with small numbers of subjects concerning resistin levels in obesity with contradictory results. Two longitudinal analyses revealed changes in serum resistin to be positively correlated with changes in fat mass or weight status 18,19 and mean insulin, 18 while other studies reported no changes of resistin in weight loss. 13,16,20 As a result of these controversial findings, the small number of longitudinal data and, most importantly, the lack of studies concerning resistin levels in children, we studied resistin serum levels in obese and lean children in relation to age, gender, puberty, and insulin resistance and measured resistin concentrations before and after weight loss.…”

Section: Introductionmentioning

confidence: 91%

Resistin concentrations before and after weight loss in obese children

et al. 2005

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Objective: The influences of gender, puberty, and obesity on resistin levels and the longitudinal relationships between insulin resistance, weight loss, and resistin have not yet been studied in childhood. Methods: Age, pubertal stage, gender, weight status (standard deviation score-body mass index (SDS-BMI)), resistin levels, and insulin resistance index calculated by homeostasis model assessment (HOMA) were evaluated in 63 obese children and compared to 36 lean children of same age, gender, and pubertal stage. Furthermore, we analyzed the changes of weight status (SDS-BMI, percentage body fat based on skinfold measurements), waist-to-hip ratio, resistin, and HOMA over a 1-year period in 38 obese children. Results: The resistin levels did not significantly (P ¼ 0.079) differ between obese (median resistin 8.7 ng/ml) and lean children (median resistin 9.7 ng/ml). Resistin concentrations were independent of age and pubertal stage, but girls demonstrated significantly higher resistin levels than boys (P ¼ 0.021). There were no significant correlations between changes of resistin and changes of SDS-BMI (r ¼ 0.14, P ¼ 0.198), changes of percentage body fat (r ¼ À0.01, P ¼ 0.466), changes of waist-to-hip ratio (r ¼ 0.17, P ¼ 0.141), and changes of insulin resistance index (r ¼ 0.01, P ¼ 0.472) over the 1-year period. The weight loss of X0.5 SDS-BMI in 16 children was associated with a significant decrease in HOMA (P ¼ 0.030), while there was no significant change in resistin levels (P ¼ 0.878). Conclusions: Girls demonstrated higher resistin concentrations than boys. Our data do not support a relationship between resistin, insulin resistance index, and weight status in childhood.

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Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines

Cited by 174 publications

References 28 publications

CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects

CRP reduction following gastric bypass surgery is most pronounced in insulin-sensitive subjects

Increase in serum resistin during weight loss in overweight subjects is related to lipid metabolism

Resistin concentrations before and after weight loss in obese children

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