Modic changes associated with greater pain relief following anesthetization of the adjacent lumbar intervertebral disc: A retrospective study of chronic low back pain patients

Korhonen, Tero; Järvinen, Jyri; Pesälä, Juha; Haapea, Marianne; Niinimäki, Jaakko

doi:10.1016/j.ejrad.2022.110589

Cited by 3 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous study showed that, the size of Modic changes and defects of cartilaginous and bony endplate were also strongly related with LBP [10][11][12] . The endplates changed into porous during intervertebral disk degeneration.…”

Section: Discussionmentioning

confidence: 93%

“…Previous studies showed that, cartilaginous endplates was hardened and porous after up the aging process, which is clinically related to LBP 30 . Previous study showed that, the size of Modic changes and defects of cartilaginous and bony endplate were also strongly related with LBP 10-12 . The endplates changed into porous during intervertebral disk degeneration.…”

Section: Discussionmentioning

confidence: 94%

“…The center of the vertebral endplate is still covered by a thin layer of hyaline cartilage, which is the cartilage endplate 8,9 . In clinical MRI examination, the size of Modic changes and defects of cartilaginous and bony endplate are also strongly related with LBP [10][11][12] . It's reported that, endplates change into porous during intervertebral disk degeneration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Targeting GDF15 as a potential therapy for low back pain originating from endplate

Kong

et al. 2023

Preprint

View full text Add to dashboard Cite

The overactivation of osteoclasts in the endplate is one of the most important causes of low back pain (LBP) originating from endplate. Transforming growth factor-β family has been demonstrated to play an important role during osteoclast differentiation. GDF15 was reported to participate in several pathological states. In this study, we reported that the lumbar spine instability (LSI) induced the overactivation of osteoclasts and CD31hiEmcnhi endothelial vessels in the bony endplate. In addition, the expression of GDF15 in human disc samples and mice models were also increased. GDF15 could promote the fusion of preosteoclasts via Rac1/Cdc42/PAK/Cofilin axis, and facilitate the angiogenesis via the secretion of PDGF-BB. Furthermore, we proved that the GDF15 inhibitor, CTL-002 could reduce the expression of GDF15 in the endplate and alleviate the overactivation of osteoclasts and CD31hiEmcnhi endothelial vessels induced by LSI in vivo. In conclusion, we demonstrated that GDF15 could regulates the fusion of preosteoclasts and targeting GDF15 in the endplate served as a novel anabolic therapy for low back pain treatment.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Targeting GDF15 as a potential therapy for low back pain originating from endplate

Kong

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Efficacy of stepped care treatment for chronic discogenic low back pain patients with Modic I and II changes

Mylenbusch,

Schepers,

Kleinjan

et al. 2023

Interventional Pain Medicine

View full text Add to dashboard Cite

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability

Czaplewski,

Rimmer,

McHale

et al. 2023

J Orthop Surg Res

View full text Add to dashboard Cite

Background Estimating the contribution of endplate oedema known as Modic changes to lower back pain (LBP) has been the subject of multiple observational studies and reviews, some of which conclude that the evidence for an association of Modic change with LBP is uncertain while others demonstrate a clear link. The clinical trials demonstrating the benefit of basivertebral nerve ablation, a therapeutic intervention, in a tightly defined homogenous patient group with chronic LBP and Modic changes type 1 or type 2, provides further evidence for the contribution of Modic changes to LBP and shows that in these subjects, nerve ablation substantially reduces pain and disability. These interventional studies provide direct evidence that Modic changes can be associated with lower back pain and disability. This review set out to explore why the literature to date has been conflicting. Methods A narrative, forensic, non-systematic literature review of selected articles to investigate why the published literature investigating the association between Modic imaging changes and chronic low back pain is inconsistent. Results This review found that previous systematic reviews and meta-analyses included both heterogeneous study designs and diverse patient syndromes resulting in an inconsistent association between Modic changes and nonspecific chronic lower back pain. Re-analysis of literature data focussing on more homogenous patient populations provides clearer evidence that Modic changes are associated with nonspecific chronic lower back pain and that type 1 Modic changes are more painful than type 2. Conclusions Studies using tightly defined homogenous patient groups may provide the best test for association between MRI-findings and pain and disability. Clinical benefit of basivertebral nerve ablation observed in randomised controlled trials further supports the association between type 1 and type 2 Modic changes with pain and disability.

show abstract

Modic changes associated with greater pain relief following anesthetization of the adjacent lumbar intervertebral disc: A retrospective study of chronic low back pain patients

Cited by 3 publications

References 47 publications

Targeting GDF15 as a potential therapy for low back pain originating from endplate

Targeting GDF15 as a potential therapy for low back pain originating from endplate

Efficacy of stepped care treatment for chronic discogenic low back pain patients with Modic I and II changes

Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability

Contact Info

Product

Resources

About