Modic Changes in Endplates of Lumbar Vertebral Bodies

Kuisma, Mari; Karppinen, Jaro; Niinimäki, Jaakko; Ojala, Risto; Haapea, Marianne; Heliövaara, Markku; Korpelainen, Raija; Taimela, Simo; Natri, Antero; Tervonen, Osmo

doi:10.1097/01.brs.0000261561.12944.ff

Cited by 241 publications

(125 citation statements)

References 26 publications

Supporting

Mentioning

112

Contrasting

Unclassified

Order By: Relevance

“…In accordance with earlier observations that MCs are rare in children [12] and young adults [26], but common in middle-aged adults [9], the current study confirmed an association between age and the presence of MCs. Moreover, older age was associated with a greater number of endplates affected and MCs of larger size.…”

Section: Discussionsupporting

confidence: 92%

“…This prevalence rate was relatively high, but is consistent with results of previous studies of MCs in 55% of Finnish male train engineers (age range 36–56 years) [9] and 49% of 44-year-old Danes [8]. According to systematic reviews MCs are more prevalent in back pain patients than in asymptomatic volunteers, in adults than in adolescents and younger children, and more common in Europeans than in Asians [23,24].…”

Section: Discussionsupporting

confidence: 89%

“…For example, the prevalence rates reported in the scientific literature widely range from 0.5% [12] to 62% [13]. Among the factors underlying the inconsistencies are variations in age and race of the subjects, back pain status [7,14] and occupation [9]. To date, there are only two reports on MCs in the general population, which come from the same cohort [8,15].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Modic changes: prevalence, distribution patterns, and association with age in white men

2012

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modic changes: prevalence, distribution patterns, and association with age in white men

2012

View full text Add to dashboard Cite

“…MCs are notably common in people who have the relevant symptoms1. The importance of MCs has been highlighted in many studies due to their association with low back pain (LBP)23. Three different types of subchondral signal abnormalities in the vertebral body marrow were first independently described by de Roos et al 4.…”

mentioning

confidence: 99%

Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China

Han

Kuang

2017

Sci Rep

View full text Add to dashboard Cite

The distribution of Modic changes (MCs) in the lumbar endplates and the evaluation of the relationships between MCs and risk factors are vital for research into MCs. The T1-weighted and T2-weighted sagittal MRI scans of 210 patients who exhibited lumbar intervertebral disc degeneration were retrospectively reviewed. The patients’ weights, genders, smoking statuses, physical activity levels and specific types of MC were recorded. The associations between MCs and risk factors, such as physical work, smoking and body mass index, were also analysed. MCs were observed in 47 patients (22.4%), including 16 males and 31 females. Among all patients, the L5/S1 lumbar level was most likely to suffer MCs. The MCs were predominantly type II. MCs occurred more often in obese patients than in normal and overweight patients (P < 0.05). Patients whose jobs required heavy labour were more likely to develop MCs (P < 0.05). Heavy work and obesity were related to type III MCs more strongly than the other types (P > 0.05). Smoking seemed not to be correlated with the incidence of MCs (P > 0.05). Gender, obesity and heavy work were strongly associated with MCs. Biomechanical factors may play a critical role in the development of MCs.

show abstract

“…A number of studies have emphasized the importance of understanding the microstructure of the endplate, especially the canal network in the endplate111217313233343536. It has been reported that nutrients are supplied to the IVD mainly via diffusion through the canals in the endplate1137.…”

Section: Discussionmentioning

confidence: 99%

3D characterization of morphological changes in the intervertebral disc and endplate during aging: A propagation phase contrast synchrotron micro-tomography study

Cao

Liao

Zeng

et al. 2017

Sci Rep

View full text Add to dashboard Cite

A better understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate is essential to elucidate the pathogenesis of IVD degeneration disease (IDDD). To date, the simultaneous depiction of 3D micro-architectural changes of endplate with aging and interaction with IVD remains a technical challenge. We aim to characterize the 3D morphology changes of endplate and IVD during aging using PPCST. The lumbar vertebral level 4/5 IVDs harvested from 15-day-, 4- and 24-month-old mice were initially evaluated by PPCST with histological sections subsequently analyzed to confirm the imaging efficiency. Quantitative assessments of age-related trends after aging, including mean diameter, volume fraction and connectivity of the canals, and endplate porosity and thickness, reached a peak at 4 months and significantly decreased at 24 months. The IVD volume consistently exhibited same trend of variation with the endplate after aging. In this study, PPCST simultaneously provided comprehensive details of 3D morphological changes of the IVD and canal network in the endplate and the interaction after aging. The results suggest that PPCST has the potential to provide a new platform for attaining a deeper insight into the pathogenesis of IDDD, providing potential therapeutic targets.

show abstract

Modic Changes in Endplates of Lumbar Vertebral Bodies

Abstract: Modic changes at L5-S1 and Modic type I lesions are more likely to be associated with pain symptoms than other types of Modic changes or changes located at other lumbar levels.

Cited by 241 publications

References 26 publications

Modic changes: prevalence, distribution patterns, and association with age in white men

Modic changes: prevalence, distribution patterns, and association with age in white men

Prevalence of Modic changes in the lumbar vertebrae and their associations with workload, smoking and weight in northern China

3D characterization of morphological changes in the intervertebral disc and endplate during aging: A propagation phase contrast synchrotron micro-tomography study

Contact Info

Product

Resources

About