Modificación de los criterios de Sgarbossa para el diagnostico de infarto agudo de miocardio en presencia de bloqueo de rama izquierda

Moreno-Ruiz, Nelson Leandro

doi:10.15446/revfacmed.v63n1.46810

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…This event leads to cardiomyocyte death [2], which is a critical consequence considering the limited regenerative capacity of the adult mammalian heart. Therefore, AMI is characterized by the loss of significant myocardium, replaced by a collagenbased scar, ischemic cardiomyocytes, and a prominent inflammatory reaction, all of which are pivotal elements in heart repair and remodeling [3].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+ and CXCR3+ in Individuals With Acute Myocardial Infarction

Moreno,

Zapata,

Gutierrez

et al. 2024

Preprint

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Acute myocardial infarction (AMI) results from vulnerable plaque rupture, causing ischemic cardiomyocyte necrosis and intense inflammation. Paradoxically, this inflammation releases factors that aid heart repair. Recent findings suggest a role for extracellular vesicles (EVs) in intercellular communication during post-AMI cardiac repair. However, EVs’ tissue origin and chemokine profile in the blood of patients with AMI remains unclear. This study characterized EV tissue origin and chemokine receptor profile in the coronary and peripheral blood of patients with AMI. The results reveal that vesicles isolated from coronary and peripheral blood plasma are enriched in tetraspanin (CD9) and express CD81+, CD90+, and CD144+. The vesicle size ranged between 145 and 162 nm, with the control group exhibiting smaller vesicles than the AMI group. Furthermore, all vesicles expressed CCR6+ and CXCR3+, whereas a small percentage expressed CCR4+. In addition, a decrease in CXCR3+ and CCR6+ positivity was observed in coronary and peripheral blood vesicles compared with the control. Non-difference was found in the coronary and peripheral blood for the CXCR3+ and CCR6+ markers. In conclusion, our study demonstrates, for the first time, changes in the number of extracellular vesicles expressing CD144+, CXCR3+, and CCR6+ in the peripheral circulation of patients with AMI. Extracellular vesicles present in the peripheral circulation of patients with AMI hold excellent promise as a potential diagnostic tool.

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Section: Introductionmentioning

confidence: 99%

Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+ and CXCR3+ in Individuals With Acute Myocardial Infarction

Moreno,

Zapata,

Gutierrez

et al. 2024

Preprint

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show abstract

“…En la tercera revisión de la definición universal en 2012 se establece que debe existir elevación de biomarcadores cardiacos por arriba del percentil 99 del límite normal superior y por lo menos una de las siguientes características: síntomas de isquemia, cambios nuevos o presumiblemente nuevos del segmento ST, bloqueo de rama izquierda del haz de His, desarrollo de Q patológica en el electrocardiograma, evidencia de pérdida del miocardio viable o nuevas alteraciones en la movilidad, evidencia en estudios de imagen de pérdida nueva de miocardio viable o alteraciones nuevas de la contractilidad del miocardio, identificación de trombo intracoronario en la angiografía o autopsia. [4][5][6][7] Existen factores de riesgo asociados al SCA que pueden estar relacionados con la evolución natural de las enfermedades cardiovasculares de acuerdo al estilo de vida o características bioquímicas y fisiológicas; los principales a tomar en cuenta son la hipertensión, diabetes, dislipidemia, tabaquismo, sedentarismo, inactividad física, obesidad, dieta aterogénica, factores psicosociales, así como el consumo de cocaína. 3,[8][9][10][11] El proceso de estratificación de riesgo por medio de la escala de riesgo TIMI es un proceso por el cual se identifican factores de riesgo que modifican el pronóstico de mortalidad temprana.…”

Section: Wwwmedigraphicorgmx Introducciónunclassified

Prevalencia del síndrome coronario agudo en primer nivel de atención

Becerra-Partida¹,

Casillas-Torres²,

Becerra-Álvarez³

2020

Revista CONAMED

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descriptiva se utilizaron frecuencias y proporciones en variables cualitativas; en las cuantitativas media, mediana, moda y desviación estándar. Resultados: De una muestra total de 121 pacientes se descartó SCA en 10.5%. De los 57 pacientes restantes, se detectó una prevalencia de sospecha y diagnóstico clínico de SCA en la UMF número 78 de 89.5%; todos ellos presentaron cuadro clínico de dolor torácico y cambios electrocardiográficos. Conclusiones: La prevalencia de sospecha y diagnóstico de SCA en la UMF número 78 en Guadalajara, Jalisco, es de 89.5%; todos ellos mostraron cuadro clínico de dolor torácico y cambios electrocardiográficos. Estos hallazgos muestran la importancia de priorizar la prevención tratando de bajar el riesgo cardiovascular al disminuir los factores de riesgo modificables y controlar de manera adecuada las patologías existentes, además de mejorar los procesos de identificación clínica, diagnóstico electrocardiográfico, tratamiento en primer nivel de atención y envío oportuno a segundo o tercer nivel. Palabras clave: Síndrome coronario agudo, primer nivel de atención, isquemia miocárdica.

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Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+, and CXCR3+ in Individuals with Acute Myocardial Infarction

Moreno,

Alarcón-Zapata,

Guzmán-Gútierrez

et al. 2024

Biomedicines

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Acute myocardial infarction (AMI) results from vulnerable plaque rupture, causing ischemic cardiomyocyte necrosis and intense inflammation. Paradoxically, this inflammation releases factors that aid heart repair. Recent findings suggest a role for extracellular vesicles (EVs) in intercellular communication during post-AMI cardiac repair. However, EVs’ tissue origin and chemokine profile in the blood of patients with AMI remains unclear. This study characterized the tissue origin and chemokine receptor profile of EVs in the coronary and peripheral blood of patients with AMI. The results reveal that vesicles isolated from coronary and peripheral blood plasma are enriched in tetraspanin (CD9) and express CD81+, CD90+, and CD144+. The vesicle size ranged between 145 and 162 nm, with the control group exhibiting smaller vesicles (D10) than the AMI group. Furthermore, all vesicles expressed CCR6 and CXCR3, whereas a small percentage expressed CCR4. In addition, a decrease in CXCR3 and CCR6 expression was observed in coronary and peripheral AMI blood vesicles compared with the control; however, no difference was found between AMI coronary and AMI peripheral blood vesicles. In conclusion, our study demonstrates, for the first time, changes in the number of extracellular vesicles expressing CD144+, CXCR3, and CCR6 in the peripheral circulation of patients with AMI. Extracellular vesicles present in the circulation of patients with AMI hold excellent promise as a potential diagnostic tool.

show abstract

Modificación de los criterios de Sgarbossa para el diagnostico de infarto agudo de miocardio en presencia de bloqueo de rama izquierda

Cited by 3 publications

References 17 publications

Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+ and CXCR3+ in Individuals With Acute Myocardial Infarction

Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+ and CXCR3+ in Individuals With Acute Myocardial Infarction

Prevalencia del síndrome coronario agudo en primer nivel de atención

Changes in the Release of Endothelial Extracellular Vesicles CD144+, CCR6+, and CXCR3+ in Individuals with Acute Myocardial Infarction

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