Modification of a conventional polyurethane composition provides significant anti-biofilm activity against <i>Escherichia coli</i>

Peng, Chao; Vishwakarma, Apoorva; Li, Zhuoran; Miyoshi, Toshikazu; Barton, Hazel A.; Joy, Abraham

doi:10.1039/c8py00492g

Cited by 30 publications

(28 citation statements)

References 21 publications

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“…After 72 h of experiments, the worms’ viability showed a ratio of 50/50 with minimal activity (scale 1) and death (scale 0) for the loaded PU matrices with 0.5 and 1.0 wt% curcumin (Table 1). The literature has reported the influence of cationic groups that provide significant antimicrobial/antifungal activities . Peng et al .…”

Section: Resultsmentioning

confidence: 99%

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One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications

Bonattini

Paula

Jesus

et al. 2020

Polymer International

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This work presents a facile one‐pot fabrication of polyurea (PU) organogels based on polyetheramine (PEO, Jeffamine ED‐2003) and a crosslinker hexamethylene diisocyanate trimer (HDI) which were subsequently used as a drug carrier to incorporate a curcumin hydrophobic molecule in aqueous conditions and for removal of an anionic pollutant in water. PU can be obtained in different shapes with easy control of film thickness with high transparency, flexibility and homogeneous dispersion of curcumin in the matrix. Due to the hydrophilic nature of PEO a high swelling degree was demonstrated by the PU gel. The phase separated domains and the temperature's influence on the system's structural order/disorder were examined by small‐angle X‐ray scattering, showing a more PU ordered system (interface between hard and soft segments) after decreasing the temperature to −90 °C. The presence of curcumin in the structure of PU was confirmed by Fourier transform infrared, photoluminescence and release studies. A highly efficient removal of Congo red dye from aqueous solution using PU as adsorbent was observed. Moreover, the effect of unloaded and curcumin‐loaded PU gels was evaluated on Schistosoma mansoni adult worms. Detailed in vitro cell viability experiments showed the biocompatibility of loaded and unloaded PU gels. The easy processability of the multifunctional PU shows that it has promising applications as transdermal and soft tissue implantable delivery devices for a large number of poorly water‐soluble drugs and as an efficient adsorbent for removal of organic dyes; it can also be used in the future in dermatological treatments against malignant melanoma. © 2020 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

“…The literature has reported the influence of cationic groups that provide significant antimicrobial/antifungal activities . Peng et al . prepared an amine‐functionalized polyurethane based on a commercial material named Tecloflex®.…”

Section: Resultsmentioning

confidence: 99%

One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications

Bonattini

Paula

Jesus

et al. 2020

Polymer International

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“…To determine the antimicrobial activity, the synthesized Ag NPs were tested for bactericidal activity against E. coli [14]. A single colony of E. coli was grown overnight at 37°C in LB medium on an orbital shaker at 150 rpm.…”

Section: Antimicrobial Activity Studiesmentioning

confidence: 99%

Biosynthesis and Antibacterial Activity of Silver Nanoparticles Using Yeast Extract as Reducing and Capping Agents

Shu¹,

He²,

et al. 2020

Nanoscale Res Lett

146

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Biosynthesis for the preparation of antimicrobial silver nanoparticles (Ag NPs) is a green method without the use of cytotoxic reducing and surfactant agents. Herein, shape-controlled and well-dispersed Ag NPs were biosynthesized using yeast extract as reducing and capping agents. The synthesized Ag NPs exhibited a uniform spherical shape and fine size, with an average size of 13.8 nm. The biomolecules of reductive amino acids, alpha-linolenic acid, and carbohydrates in yeast extract have a significant role in the formation of Ag NPs, which was proved by the Fourier transform infrared spectroscopy analysis. In addition, amino acids on the surface of Ag NPs carry net negative charges which maximize the electrostatic repulsion interactions in alkaline solution, providing favorable stability for more than a year without precipitation. The Ag NPs in combination treatment with ampicillin reversed the resistance in ampicillinresistant E. coli cells. These monodispersed Ag NPs could be a promising alternative for the disinfection of multidrugresistant bacterial strains, and they showed negligible cytotoxicity and good biocompatibility toward Cos-7 cells.

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“…Another study by Li et al showed that cationic monomer, methacryloxylethylcetyl dimethyl ammonium chloride (DMAE-CB) was also effective in the removal of a biofilm of S. mutans , the common bacteria associated dental problems [ 164 ]. Peng et al modified the polyurethane compound, the main compound for catheter by copolymerization of an amine functionalized N-substituted diol to give a cationic polyurethane (Tecoflex-NH3), and showed that the cationic polyurethane shown contact killing of E. coli and prevent build-up of biofilm on the surfaces, thus, reducing the chances of CAUTI, one of the main causes of the nosocomial infections [ 165 ]. Another example of an antimicrobial polymer is Polyhexamethlene biguanide (PHMB), a cationic polymer that has been used in the clinic for over than 40 years with no sign of bacterial resistance [ 166 ].…”

Section: Promising Novel Therapies For Prevention and Treatment Ofmentioning

confidence: 99%

Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm

et al. 2018

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Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumoniae (K. pneumoniae) on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections.

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Modification of a conventional polyurethane composition provides significant anti-biofilm activity against Escherichia coli

Abstract: Tecoflex-NH3+ exhibited a contact-killing mechanism and showed excellent anti-biofilm properties against E. coli even after 5 days.

Cited by 30 publications

References 21 publications

One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications

One‐step formation of polyurea gel as a multifunctional approach for biological and environmental applications

Biosynthesis and Antibacterial Activity of Silver Nanoparticles Using Yeast Extract as Reducing and Capping Agents

Targeting the Bacterial Protective Armour; Challenges and Novel Strategies in the Treatment of Microbial Biofilm

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