Modification of curcumin-loaded liposome with edible compounds to enhance ability of crossing blood brain barrier

Chen, Mei-Huei; Chiang, Been‐Huang

doi:10.1016/j.colsurfa.2020.124862

Cited by 27 publications

(8 citation statements)

References 50 publications

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“…47 Various types of vesicular drug delivery systems such as liposome, niosome, transfersome, and ethosome have been developed (Table 1). [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65]…”

Section: Vesicular Systems In Phytosome Developmentmentioning

confidence: 99%

“… [ 62 ] Curcumin Fast permeation rate endothelial cell monolayer crossing blood-brain barrier (BBB) and good durability toward digestive enzymes. [ 61 ] Eleusine coracana Effective antibacterial formulations have a great nutritive value. [ 60 ] Niosome Carum carvi Regulate release and decrease of MCF-7 cell migration, high anti-cancer behavior against MCF-7 supported by cytometry flow (G2/M arrest).…”

Section: Vesicular Systems In Phytosome Developmentmentioning

confidence: 99%

“… 35 Chen et al also prepared curcumin-liposomes, and TGA and FTIR showed a successful presence of SA and PSA in liposomal lipid bilayers and covalent bonding between SA carboxyl group and WGA amine group. 61 …”

Section: Phytosome Characterizationmentioning

confidence: 99%

See 2 more Smart Citations

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Barani¹,

Sangiovanni²,

Angarano³

et al. 2021

IJN

136

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Nowadays, medicinal herbs and their phytochemicals have emerged as a great therapeutic option for many disorders. However, poor bioavailability and selectivity might limit their clinical application. Therefore, bioavailability is considered a notable challenge to improve bio-efficacy in transporting dietary phytochemicals. Different methods have been proposed for generating effective carrier systems to enhance the bioavailability of phytochemicals. Among them, nano-vesicles have been introduced as promising candidates for the delivery of insoluble phytochemicals. Due to the easy preparation of the bilayer vesicles and their adaptability, they have been widely used and approved by the scientific literature. The first part of the review is focused on introducing phytosome technology as well as its applications, with emphasis on principles of formulations and characterization. The second part provides a wide overview of biological activities of commercial and non-commercial phytosomes, divided by systems and related pathologies. These results confirm the greater effectiveness of phytosomes, both in terms of biological activity or reduced dosage, highlighting curcumin and silymarin as the most formulated compounds. Finally, we describe the promising clinical and experimental findings regarding the applications of phytosomes. The conclusion of this study encourages the researchers to transfer their knowledge from laboratories to market, for a further development of these products.

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Section: Vesicular Systems In Phytosome Developmentmentioning

confidence: 99%

Section: Vesicular Systems In Phytosome Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Barani¹,

Sangiovanni²,

Angarano³

et al. 2021

IJN

136

View full text Add to dashboard Cite

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“… Carriers used for the delivery of curcumin for Alzheimer’s treatment for in vivo studies [ 6 , 39 , 60 , 75 , 145 , 146 , 147 , 148 ]. …”

Section: Figurementioning

confidence: 99%

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Ege

2021

Materials

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AD is a chronic neurodegenerative disease. Many different signaling pathways, such as Wnt/β-catenin, Notch, ROS/JNK, and PI3K/Akt/mTOR are involved in Alzheimer’s disease and crosstalk between themselves. A promising treatment involves the uses of flavonoids, and one of the most promising is curcumin; however, because it has difficulty permeating the blood–brain barrier (BBB), it must be encapsulated by a drug carrier. Some of the most frequently studied are lipid nanocarriers, liposomes, micelles and PLGA. These carriers are further conjugated with brain-targeting agents such as lactoferrin and transferrin. In this review paper, curcumin and its therapeutic effects, which have been examined in vivo, are analyzed and then the delivery systems to the brain are addressed. Overall, the analysis of the literature revealed great potential for curcumin in treating AD and indicated the challenges that require further research.

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“…Moreover, the modified phospholipids, contributed to denser lipid packing in liposomal membranes. In another paper, the authors modified CUR-loaded liposomes with edible compounds to improve their ability to cross the blood–brain barrier [ 141 ]. More in detail, the research explored the potential of food grade sialic acid, polymerized sialic acid, and their oxidized forms to conjugate with wheat germ agglutinin on liposomes to deliver CUR to the brain.…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Progress in Colloid Delivery Systems for Protection and Delivery of Phenolic Bioactive Compounds: Two Study Cases—Hydroxytyrosol and Curcumin

et al. 2022

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Insufficient intake of beneficial food components into the human body is a major issue for many people. Among the strategies proposed to overcome this complication, colloid systems have been proven to offer successful solutions in many cases. The scientific community agrees that the production of colloid delivery systems is a good way to adequately protect and deliver nutritional components. In this review, we present the recent advances on bioactive phenolic compounds delivery mediated by colloid systems. As we are aware that this field is constantly evolving, we have focused our attention on the progress made in recent years in this specific field. To achieve this goal, structural and dynamic aspects of different colloid delivery systems, and the various interactions with two bioactive constituents, are presented and discussed. The choice of the appropriate delivery system for a given molecule depends on whether the drug is incorporated in an aqueous or hydrophobic environment. With this in mind, the aim of this evaluation was focused on two case studies, one representative of hydrophobic phenolic compounds and the other of hydrophilic ones. In particular, hydroxytyrosol was selected as a bioactive phenol with a hydrophilic character, while curcumin was selected as typical representative hydrophobic molecules.

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Modification of curcumin-loaded liposome with edible compounds to enhance ability of crossing blood brain barrier

Cited by 27 publications

References 50 publications

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature

Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery

Progress in Colloid Delivery Systems for Protection and Delivery of Phenolic Bioactive Compounds: Two Study Cases—Hydroxytyrosol and Curcumin

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