Modification of DNA by Alkylating Compounds

Abstract

The problem of the sS content in the nucleon is discussed. In the framework of the generalized NambuJona-Lasinio model we estimate the parameter p of the Zweig rule violation and the critical temperature T, of the chiral-symmetry restoration.

A Critical Appraisal of the Evolution ofN-Nitrosoureas as Anticancer Drugs

“…Alkylation of nucleic acids is considered , to be responsible for the cytotoxicity of the CENUs while the carbamoylation of proteins was the cause of the toxic side effects of these antitumor agents. , Reviews have been published concerning the alkylation of DNA by a variety of alkylating agents 714 and by N -nitrosoureas − in particular.…”

“…715,716 Structures of the modified bases were determined by the combination of ultraviolet spectroscopy, 715,716 mass spectrometry of underivatized bases and their corresponding trimethylsilylated nucleoside derivatives, 714,715 and the synthesis of the modified bases. [723][724][725]727 A number of modified heterobases of nucleotides have been determined [715][716][717][718][719][720][721] from studies of the CENUs with synthetic polynucleotides and DNA (Figure 3). The modified bases can be divided in two types i.e.…”