Modification of embolic‐PVA particles with MR contrast agents

Cilliers, Renee; Song, Ying; Kohlmeir, Ellen K.; Larson, Andrew C.; Omary, Reed A.; Meade, Thomas J.

doi:10.1002/mrm.21518

Cited by 24 publications

(17 citation statements)

References 15 publications

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“…The later is a promising approach and has been successfully employed by attaching gadolinium complexes to high molecular weight platforms such as cyclodextrins, 22,23 dendrimers [24][25][26][27][28] and less well defined polymers. 21,29,30 Besides their potential beneficial effect in slowing tumbling, high molecular weight materials also have the advantage of increasing the load of gadolinium per molecule with the consequent increase in relaxivity. 31 Another interesting approach that has been gaining terrain recently is the development of lanthanide-based MRI contrast agents that operate via the chemical exchange saturation transfer (CEST) mechanism.…”

Section: Introductionmentioning

confidence: 99%

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

Martinelli

Balali-Mood

Panizzo³

et al. 2010

Dalton Trans.

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Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substitited ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared.The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented.

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Section: Introductionmentioning

confidence: 99%

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

Martinelli

Balali-Mood

Panizzo³

et al. 2010

Dalton Trans.

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“…18,[22][23][24]30 However, to the best of our knowledge, directly visible particulate embolization particles have never been evaluated in a clinical setting. Furthermore, multimodal-visible particles have not been discussed so far.…”

Section: Discussionmentioning

confidence: 96%

“…Similarly, the same arguments hold true for noncovalent doping of particles with MRI contrast media. 24,32 Intrinsically visible particles, as presented in this study, would allow real-time control of particle placement, regardless of whether they are applied under fluoroscopic, CT, or MRI control. Multimodal visibility of the particles could be of special interest in procedures requiring long imaging to detect the moment of beginning reflux during embolization.…”

Section: Discussionmentioning

confidence: 98%

“…22 Directly visible embolization materials may provide advantages over nonvisible embolization particles for embolization control and therapy follow-up. 18,[22][23][24] Therefore, the motivation of our research was to design a directly visible embolization material by developing a multimodal embolization particle that is visible in more than one imaging modality, namely x-ray/CT and MRI. Its ability to provide image contrast in angiography, CT, and MRI was tested in vitro and in vivo; furthermore, its ability to embolize tissue was demonstrated in an established rabbit tumor embolization model.…”

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confidence: 99%

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First Multimodal Embolization Particles Visible on X-ray/Computed Tomography and Magnetic Resonance Imaging

Bartling¹,

Budjan²,

Aviv³

et al. 2011

Investigative Radiology

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Multimodal-visible embolization particles have been developed, characterized, and tested in vivo in an animal model. Their implementation in clinical radiology may provide optimization of embolization procedures with regard to prevention of particle misplacement and direct intraprocedural visualization, at the same time improving follow-up examinations by utilizing the complementary characteristics of CT and MRI. Radiation dose savings can also be considered. All these advantages could contribute to future refinements and improvements in embolization therapy. Additionally, new approaches in embolization research may open up.

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“…Alternatively, magnetic resonance imaging (MRI) technology recently plays an important role in the field of medical imaging diagnosis. MRI can not only track where the embolic agents are located precisely on real time [12][13][14][15][16] but also prevent the patient from the radiation hazards. 17,18 In the MRI technology, superparamagnetic iron oxide nanoparticles (SPIO NPs) are usually added into embolic agents to endow them with enhanced MRI visuality.…”

Section: Introductionmentioning

confidence: 99%

Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

Wang¹,

Liu²,

Yang³

et al. 2017

IJN

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Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres. The release behavior of dual drugs from the microspheres show typical sustained release profiles. As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized.

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Modification of embolic‐PVA particles with MR contrast agents

Cited by 24 publications

References 15 publications

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

First Multimodal Embolization Particles Visible on X-ray/Computed Tomography and Magnetic Resonance Imaging

Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

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