“…Modulation of glycan expression, particularly with regard to changes in asparagine-linked oligosaccharides, has been shown to be essential for cellular transformations in colorectal cancer (CRC) [39,60]. Moreover, among the various posttranslational modifications, glycosylation is reported to be the most common, and approximately half of all known proteins are glycosylated [61]. Knockdown of the first N-glycosylation gene, ALG7, in two genetically distinct haploid yeast cells resulted in an unexpected phenotype of mitochondrial dysfunction, indicating promise for future drug development [62].…”