Modification of Pullorum Disease in the Chick by Certain Tricarboxylic Acid Cycle Inhibitors and Intermediates

Abstract

It is now known (Ross et al., 1955a, b, 1956) that the chick undergoes an altered protein metabolism when infected with Salmonella pullorum. This knowledge has suggested that the carbo

INFLUENCE OF SALMONELLA PULLORUM INFECTION ON VARIOUS LIVER TRICARBOXYLIC ACID ENZYMES AND CITRATE LEVELS IN THE CHICK

“…White Leghorn cockerels, 1 to 3 days old, weighing 34 i 2 g, and obtained from pullorumfree flocks, were injected intraperitoneally with approximately 103 viable celLs of S. pullorum CDC 03562/51. The inoculum was prepared as described in a previous publication (Gilfillan et al 1956).…”

“…It has been shown (Gilfillan et al 1956) that sublethal concentrations of tricarboxylic acid (TCA) cycle inhibitors and intermediates reduce survival time in 1-to 3-day-old chicks infected with Salmonella pullorum. A correlation was also indicated between survival time and concentration of the organisms in various tissues of chicks treated with fluoroacetate.…”