Modification of Radioresponse of Sublethally Irradiated Mouse Jejunum by Misonidazole

Modification Of Radiation-Induced Chromosome Damage And Micronucleus Induction In Mouse Bone Marrow By Misonidazole And Hyperthermia

“…using a single radiation dose of 3.0 Gy (7). A similar effect was also observed for jejunal mucosa of mice treated with 1 .O g/kg MISO before acute sublethal exposures (8). Denekamp et al (18) had earlier reported that MISO showed no demonstrable sensitizing effect on well-oxygenated cells in vivo.…”

“…MISO is reported as preferentially sensitizing the hypoxic cells ( I ) . However, some radiosensitization was also demonstrated in normal oxic tissues, including mouse skin ( 5 ) and testis (6), whereas no significant sensitizing effect was observed for mouse bone marrow (7) or jejunal mucosa (8). HT is reported to kill bone marrow cells in vivo (9).…”

Cytoprotective Potential of Rutin and Quercetin in Swiss Mice Exposed to Gamma Radiation

“…Stem cells of the crypts get sterilized by lethal irradiation, subsequently the crypts shrink and disappear within 2-3 days; transit cells however continue to divide for a few divisions and migrate to the villus, which itself is lost within 3-5 days leading to manifestation of gastrointestinal syndrome [38][39] . In our study, a dose of 12 Gy caused damage to GI system and especially to the stem cells in the crypts, which is in agreement with earlier studies [38][39][40][41][42] . It was clearly observed from the gross histopthalogical section of jejunum of the present study that pre-treatment with RUT and QRT restored the crypt architecture with an elevation in crypt and goblet cell number in 24 hours of post incubation.…”

“…It was clearly observed from the gross histopthalogical section of jejunum of the present study that pre-treatment with RUT and QRT restored the crypt architecture with an elevation in crypt and goblet cell number in 24 hours of post incubation. These results are in good agreement with earlier reports, where WR-2721, MPG, vitamin E, and Mentha piperita has been reported to protect against the radiation-induced goblet cell changes in intestinal mucosa of irradiated mice [40][41][42][43][44][45][46] . The GI protection rendered by RUT and QRT may be either directly or indirectly by decreasing the damage to crypt cells through the protection against vascular endothelial injury in the GI tract thereby retaining the intestinal function by facilitating proper absorption of the nutrients contributing to increased animal survival.…”