2024
DOI: 10.3389/fnut.2024.1505584
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Modification of the active centre of nattokinase to enhance its thermostability using a strategy based on molecular dynamics simulation, steered dynamics simulation, and conservative prediction

Yuan Li,
Wenhui Zhu,
Liangqi Chen
et al.

Abstract: IntroductionThe poor thermostability of nattokinase represents a significant limitation in its potential applications. Additionally, there is a notable absence of studies focused on modifying residues within the active site region of nattokinase with the aim of enhancing its catalytic properties. Furthermore, the direct utilisation of directed evolution often yields unfavourable outcomes, with a considerable workload being a common consequence.MethodsIn order to solve the above problems, a new method based on … Show more

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