Modification of the Analgetic Effect in Relation to the Development Stage in Rats

Nicák, A; Masnyk, S.

doi:10.1159/000135794

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1978

1993

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Cited by 4 publications

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“…The analgesic effect increases between day 5 and day 15 after which it decreases to reach a steady value at day 30. The decreased sensitivity to morphine after day 15 was reported by Nicak & Masnyk (1966), Way (1967) and Johannesson & Becker (1973). It is best explained (Way, 1967) by the formation of the bloodbrain barrier which regulates penetration of drugs into brain according to their lipophilicity; our results agree with this conclusion.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Morphine Analgesia and Cerebral Opiate Receptors: A Developmental Study

Auguy-Valette

Cros

Gouardères

et al. 1978

British J Pharmacology

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Section: Discussionsupporting

confidence: 89%

“…Toxicity of morphine decreases with age (Kupferberg & Way, 1963). Nicak & Masnyk (1966) and Johannesson & Becker (1973) have shown that the analgesic activity of morphine decreased after day 14 in rats. These changes have been attributed to the development of the blood-brain barrier (Kupferberg & Way, 1963;Way, Costley & Way, 1965).…”

Section: Introductionmentioning

confidence: 99%