Modification of the existing maximum residue level for boscalid in honey

Anastassiadou, Maria; Brancato, Alba; Cabrera, Luis Carrasco; Greco, Luna; Jarrah, Samira; Kazocina, Aija; Leuschner, Renata; Magrans, José Oriol; Miron, Ileana; Nave, Stéfanie; Pedersen, Ragnor; Reich, Hermine; Rojas, Alejandro; Sacchi, Angela; Santos, Miguel; Stanek, Alois; Theobald, Anne; Vagenende, Bénédicte; Verani, Alessia

doi:10.2903/j.efsa.2019.5897

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…According to the allowable tolerances established in the Code of the Federal Regulations at 40 CFR § 180.589, the boscalid residual was set on various plant commodities ranging from 0.05 ppm in peanuts to 1 ppm on leafy vegetable (group 4), and up to the maximum at 150 ppm on herbs (subgroup 19A). The acceptable daily intake limit Literature Review for boscalid according to the framework of peer review under Council Directive 91/414/EEC, was set at 0.04 mg/kg/bw/day [50].…”

Section: Boscalidmentioning

confidence: 99%

Nature-derived nanocellulose as a platform to modulate bioavailability of biomolecules in the gastrointestinal tract

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Exploitation of nature-derived materials has become popular due to growing environmental concerns. Among these materials explored, cellulose is of particular interest because of its abundance, relative ease of access, and significant waste streams. Recently, cellulose nanofiber (CNF) has been proven to have the ability to modulate the digestion and absorption of lipids in a high-fat diet. The overarching hypothesis in this project is that CNF can be modified to modulate the bioavailability, digestion, and uptake of food ingredients and toxins in the GIT by forming inclusion complexes and promoting interacting with surface hydroxyl groups.The surface chemistry and surface properties of pristine CNF, obtained from wood pulp, were first characterized to build the fundamental knowledge for subsequent interaction studies. Next, CNF was successfully functionalized with (2hydroxypropyl)-β-cyclodextrin (HPBCD) using citric acid (CA) as a crosslinker via esterification. Functionally, the potential for pristine and functionalized CNF (FCNF) to interact with boscalid was tested.In vitro simulated GIT platform was adopted to study the adsorption of boscalid on the CNF/FCNF in the GIT, as well as the interaction of nanocellulose in the presence of high-fat food model. FCNF was found to have a slightly better effect in binding boscalid and have greater effect in retarding the triglycerides (TG) digestion than CNF. Nano-isothermal calorimetry (Nano-ITC) was conducted to study the interaction of various compounds present in the GIT. Corona studies confirmed that remnant proteins and lipids are preserved as "hard corona" on the surface of CNF/FCNF. This project sought to demonstrate the substantial potential for CNF to be used as a modulation platform to mitigate food digestion and uptake in the GIT. It was found that FCNF had excellent performance in reducing fat absorption and higher removal rate of boscalid from human body. FCNF has great potential to be designed into a 2-in-1 dietary supplement with weight loss and pesticide removal purposes.

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Section: Boscalidmentioning

confidence: 99%

Nature-derived nanocellulose as a platform to modulate bioavailability of biomolecules in the gastrointestinal tract

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Modification of the existing maximum residue level for boscalid in pomegranates

Anastassiadou¹,

Bernasconi²,

Brancato³

et al. 2020

EFS2

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In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant BASF SE submitted a request to the competent national authority in Greece to modify the existing maximum residue level (MRL) for the active substance boscalid in granate apples/pomegranates. The data submitted in support of the request were found to be sufficient to derive an MRL proposal for pomegranates. Adequate analytical methods for enforcement are available to control the residues of boscalid in the commodity under consideration at the validated limit of quantification (LOQ) of 0.01 mg/kg. Based on the risk assessment results, EFSA concluded that the long-term intake of residues resulting from the use of boscalid according to the reported agricultural practice is unlikely to present a risk to consumer health. The reliable end points, appropriate for use in regulatory risk assessment are presented.

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Scientific support for preparing an EU position for the 52nd Session of the Codex Committee on Pesticide Residues (CCPR)

2021

EFS2

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In accordance with Article 43 of Regulation ( EC ) 396/2005, EFSA received a request from the European Commission to provide support for the preparation of the EU position for 52nd session of the Codex Committee on Pesticide Residues ( CCPR ). In 2019, JMPR evaluated 20 active substances regarding the setting of toxicological reference values to be used in consumer risk assessment (acetochlor, boscalid, chlorothalonil, cyprodinil, dicamba, mesotrione, metaflumizone, thiabendazole, afidopyropen, buprofezin, clethodim, dimethoate, metconazole, omethoate, pyflubumide, pyridate, pyrifluquinazon, tolclofos‐methyl, triflumuron, valifenalate) and 47 active substance regarding the setting of Maximum Residue Limits ( MRL s) (acetochlor, azoxystrobin, boscalid, chlorantraniliprole, chlorothalonil, cyantraniliprole, cyprodinil, dicamba, fenazaquin, flonicamid, flupyradifurone, fosetyl‐Al, glyphosate, mesotrione, metaflumizone, S‐methoprene, pendimethalin, spirotetramat, tebuconazole, thiabendazole, acetamiprid, afidopyropen, benzovindiflupyr, bifenthrin, buprofezin, carbendazim, clethodim, cyclaniliprole, cypermethrins, dimethoate, fluazifop‐p‐butyl, fluensulfone, kresoxim‐methyl, mandestrobin, metconazole, omethoate, penthiopyrad, picoxystrobin, pydiflumetofen, pyflubumide, pyrifluquinazon, pyriofenone, pyriproxyfen, tolclofos‐methyl, tolfenpyrad, triflumuron, valifenalate). EFSA prepared comments on the Codex MRL proposals and the proposed toxicological reference values. In addition, EFSA provided the views on follow‐up assessments of JMPR on pesticides where specific concerns were raised in the previous CCPR meetings. The current report should serve as the basis for deriving the EU position for the CCPR meeting.

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Modification of the existing maximum residue level for boscalid in honey

Cited by 5 publications

References 8 publications

Nature-derived nanocellulose as a platform to modulate bioavailability of biomolecules in the gastrointestinal tract

Nature-derived nanocellulose as a platform to modulate bioavailability of biomolecules in the gastrointestinal tract

Modification of the existing maximum residue level for boscalid in pomegranates

Scientific support for preparing an EU position for the 52nd Session of the Codex Committee on Pesticide Residues (CCPR)

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