Modifications in SENV DNA Detection and/or SENV Subtype Determination over a Prospective Follow-Up in a Cohort of HIV-Positive Patients: Is This a Moving Target?

Quiros-Roldan, Eugenia; Torti, Carlo; Pirovano, Silvia; Moretti, Francesca; Casari, Salvatore; Carosi, Giampiero; Soriano, Vincent

doi:10.1159/000080879

Cited by 3 publications

(2 citation statements)

References 24 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SENV superinfection with multiple variants is also frequent in HIVpositive patients [16,17] . These results strongly suggest that infection with one SENV variant most likely does not protect against infection with another SENV variant.…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of SEN Virus Infection in Patients on Maintenance Hemodialysis: Frequent Mixed Infections with Different Variants and Evidence for Nosocomial Transmission of the Virus

Pirovano

Gregorini²,

Malacarne³

et al. 2005

Intervirology

Self Cite

View full text Add to dashboard Cite

Objective: The SEN virus (SENV) represents a recently described group of DNA viruses, two members of which (SENV-D and SENV-H) are linked with posttransfusion hepatitis. Since patients on hemodialysis have a high risk of being infected by blood-borne viruses, we investigated the prevalence of seven SENV isolates in two distinct units of our hospital. Methods: The presence of SENV was investigated in 171 hemodialysis patients and in 163 controls by using a polymerase chain reaction based methodology, with which the specificity of amplified products was detected by hybridization with probes specific for each variant. Polymerase chain reaction products from 4 patients were sequenced. Results: The overall detection of SENV DNA as well as of SENV-D, SENV-E, and SENV-G was significantly higher in one of the two units, and there was a higher degree of homology in the sequences prepared from patients of the same unit. Furthermore, we demonstrated that mixed infections with multiple SENV were common. No relationship was observed between presence of SENV and sex, age, duration of hemodialysis, previous transfusions or transplantation, hepatitis infection, and routine liver test results. Conclusion: Our results indicate that patients who undergo hemodialysis can be at high risk of SENV transmission and suggest an intraunit transmission of specific SENV variants.

show abstract

Section: Discussionmentioning

confidence: 99%

High Prevalence of SEN Virus Infection in Patients on Maintenance Hemodialysis: Frequent Mixed Infections with Different Variants and Evidence for Nosocomial Transmission of the Virus

Pirovano

Gregorini²,

Malacarne³

et al. 2005

Intervirology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In fact, mean duration of PD in SEN-V-D(+) patients was lower than in SEN-V(-) patients. SEN-V viremia may disappear as time passes in longitudinal studies (13). Another possibility is that, somehow, the settings of PD may protect patients from new infection by SEN-V.…”

Section: Discussionmentioning

confidence: 99%

Sen Virus Infection in Patients on Peritoneal Dialysis

Hsu

Wang

et al. 2007

Perit Dial Int

View full text Add to dashboard Cite

Background Many reports have demonstrated SEN virus (SEN-V) infection rates in hemodialysis patients, but the SEN-V infection rate in peritoneal dialysis (PD) patients has never been reported. In this study, we determined the prevalence rate of SEN-V viremia in a PD population. Methods Serum samples from 47 PD patients and a control group of 43 subjects from the general population at their health examination were assayed for SEN-V-D and -H viremia using polymerase chain reaction. Results The proportions of female gender ( p = 0.001), previous transfusion ( p < 0.0001), and higher mean serum AST level ( p = 0.012) were significantly higher in PD patients. The prevalence rates of SEN-V-D and/or -H viremia were not significantly different between PD patients and controls (27.7% vs 32.6%). SEN-V-D(+) patients had lower mean duration of PD than SEN-V(–) patients. Mean ALT level was significantly lower in SEN-V-H(+) than in SEN-V(–) patients (12.8 ± 5.8 vs 19.6 ± 12.1 (IU/L), p = 0.025). None of the SEN-V-infected PD patients had overt clinical or biochemical signs of liver disease. There were no statistically significant differences in prevalence of SEN-V-D and/or -H viremia between automated PD (APD) patients and continuous ambulatory PD (CAPD) patients. Conclusions These results indicate that the SEN-V infection rate is not different between healthy individuals and PD patients. Infection with SEN-V is not associated with evident liver disease in PD patients and SEN-V infection rate is not different between APD patients and CAPD patients.

show abstract

Potential role of SEN virus on liver enzyme abnormalities in patients positive for hepatitis C virus with or without HIV infection

Quiros-Roldan

Moretti

Torti

et al. 2005

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Modifications in SENV DNA Detection and/or SENV Subtype Determination over a Prospective Follow-Up in a Cohort of HIV-Positive Patients: Is This a Moving Target?

Cited by 3 publications

References 24 publications

High Prevalence of SEN Virus Infection in Patients on Maintenance Hemodialysis: Frequent Mixed Infections with Different Variants and Evidence for Nosocomial Transmission of the Virus

High Prevalence of SEN Virus Infection in Patients on Maintenance Hemodialysis: Frequent Mixed Infections with Different Variants and Evidence for Nosocomial Transmission of the Virus

Sen Virus Infection in Patients on Peritoneal Dialysis

Potential role of SEN virus on liver enzyme abnormalities in patients positive for hepatitis C virus with or without HIV infection

Contact Info

Product

Resources

About