Modified Bladder Outlet Obstruction Index for Powerful Efficacy Prediction of Transurethral Resection of Prostate with Benign Prostatic Hyperplasia

Abstract

Background：The correlation between modified bladder outlet obstruction index (MBOOI) and surgical efficacy still remains unknown. The purpose of the study was to investigate the clinical value of the MBOOI and its use in predicting surgical efficacy in men receiving transurethral resection of the prostate (TURP).Methods ：A total of 403 patients with benign prostate hyperplasia (BPH) were included in this study. The International Prostate Symptom Score (IPSS), quality of life (QoL) index, transrectal ultrasonography, and pressure flow study (PFS) were conducted for all patients. The bladder outlet obstruction index (BOOI) (PdetQmax -2Qmax) and MBOOI (Pves-2Qmax) were calculated. All patients underwent TURP, and surgical efficacy was accessed by the improvements in IPSS, QoL, and Qmax 6 months after surgery. The association between surgical efficacy and baseline factors was statistically analyzed.Results：A comparison of effective and ineffective groups based on the overall efficacy showed that significant differences were observed in PSA, Pves, PdetQmax, Pabd, BOOI, MBOOI, TZV, TZI, IPSS-t, IPSS-v, IPSS-s, Qmax, and PVR at baseline (P<0.05). Compared with BOOI, the results of Pearson’s correlation analysis showed that there was a more optimal correlation of MBOOI with preoperative variables, as well as with the changes postoperative(P<0.05). Binary logistic regression analysis suggested that MBOOI was the only baseline parameter correlated with the improvements in IPSS, QoL, Qmax, and the overall efficacy. Additionally, the ROC analysis further verified that MBOOI was more optimal than BOOI, TZV and TZI in predicting the surgical efficacy.Conclusion：Compared to BOOI, MBOOI may be a more useful factor that can be used to predict the surgical efficacy of TURP.Trial registration: retrospectively registered.