Modified Chitosan‐Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen

Abstract

The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6Å to 19.6Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod-CS/MMT steadily and was pH dependent.

Chitosan-Montmorillonite Polymer Composites: Formulation and Evaluation of Sustained Release Tablets of Aceclofenac

“…Depending upon the extent of deacetylation, different grades of chitosan are available. Due to its gel-forming property, it has been used in the development of various drug delivery systems [3]. Chitosan has been extensively investigated for several decades for molecular separation, food packaging film, artificial skin, bone substitutes, water engineering, and so on, owing to its good mechanical properties, biocompatibility, biodegradability, multiple functional groups as well as solubility in aqueous medium.…”

Biodegradation and bioresorption of poly(ɛ-caprolactone) nanocomposite scaffolds

“…The scaffolds with clay have peaks of Al and Si which are from MMT. [14]. In the case of CS-MMT, the characteristic peak of Na + -MMT was shifted to a much lower angle of 2Â = 5.42 • corresponding to an interlayer spacing (d 0 0 1 ) of 1.64 nm.…”

Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems

“…Chitosan has been formulated with montmorillonite to prepare hybrid composites (Lin et al 2005;Depan et al 2009;Monvisade and Siriphannon 2009;Abdeen and Salahuddin 2013;Bothiraja et al 2014). Because chitosan is positively charged, it adsorbs to the negatively charged montmorillonite interlayer (Fig.…”

“…In many cases, increasing the montmorillonite content decreases the drug release rate. In addition, incorporating montmorillonite decreases swellability of formulation (Cojocariu et al 2012a;Abdeen and Salahuddin 2013). An ofloxacin-loaded chitosan hydrogel shows fast drug release under a low pH condition, but montmorillonite decreased the release rate (Hua et al 2010b).…”