Modified Enucleation for Choroidal Melanoma with Large Extrascleral Extension

Fusetti, Stefano; Parrozzani, Raffaele; Urban, Francesca; Gurabardhi, Maceda; Ferronato, Giuseppe; Midena, Edoardo

doi:10.3109/01676830903294883

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…7 Treatment options for extrascleral uveal melanomas and their recurrences depend on the extent of local involvement and the presence of metastatic disease and involve globe-sparing plaque or external irradiation, (extended) enucleation, or exenteration followed by external beam radiotherapy or brachytherapy. 2,8 Adjuvant radiotherapy is aimed at achieving local control in residual disease following surgery. In one series, an orbital recurrence after enucleation, measuring approximately 3 × 4 cm, was treated with brachytherapy and reported disease-free at 6 months.…”

Section: Discussionmentioning

confidence: 99%

Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration

Weber

Flatz²,

Sommacal³

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A 59-year-old male patient who suffered from a systemically metastasized, large extrascleral uveal melanoma recurrence of the left eye presented with active hemorrhage from the tumor. He had undergone proton beam irradiation for an epithelioid ciliary body melanoma 4 years before presentation and was lost to follow-up. Magnetic resonance angiography showed vascularization of the lesion via the ophthalmic and maxillary artery. Selective transarterial embolization of the tumor was conducted with polyvinyl alcohol microparticles followed by coiling of the supplying arteries. The bleeding stopped after 2 days and the tumor started to become necrotic. As tumor removal was the primary wish of the patient at this point in time, exenteration was carried out a week later without significant blood loss, intraoperative or postoperative complications. Socket healing was adequate, and the patient reported improved quality of life. He refused systemic palliative treatment and died 3 months after the intervention.

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Section: Discussionmentioning

confidence: 99%

Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration

Weber

Flatz²,

Sommacal³

et al. 2021

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…One of the advantages of MRI compared to ultrasound and fundoscopy is that the complete orbit can be evaluated. This allows for a more accurate screening for extrascleral extension, optic nerve invasion and inflammatory processes [11,15,[27][28][29][30][82][83][84][85][86][87][88][89][90][91][92][93][94][95]. MRI generally outperforms ultrasound in screening for extrascleral extension (Figure 3C) [27][28][29][30].…”

Section: Anatomical Evaluationmentioning

confidence: 99%

Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients—A Systematic Review from an Ophthalmic Perspective

Jaarsma-Coes

Klaassen

Marinković

et al. 2023

Cancers

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Conversely to most tumour types, magnetic resonance imaging (MRI) was rarely used for eye tumours. As recent technical advances have increased ocular MRI’s diagnostic value, various clinical applications have been proposed. This systematic review provides an overview of the current status of MRI in the clinical care of uveal melanoma (UM) patients, the most common eye tumour in adults. In total, 158 articles were included. Two- and three-dimensional anatomical scans and functional scans, which assess the tumour micro-biology, can be obtained in routine clinical setting. The radiological characteristics of the most common intra-ocular masses have been described extensively, enabling MRI to contribute to diagnoses. Additionally, MRI’s ability to non-invasively probe the tissue’s biological properties enables early detection of therapy response and potentially differentiates between high- and low-risk UM. MRI-based tumour dimensions are generally in agreement with conventional ultrasound (median absolute difference 0.5 mm), but MRI is considered more accurate in a subgroup of anteriorly located tumours. Although multiple studies propose that MRI’s 3D tumour visualisation can improve therapy planning, an evaluation of its clinical benefit is lacking. In conclusion, MRI is a complementary imaging modality for UM of which the clinical benefit has been shown by multiple studies.

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Enucleation for Ocular Tumors

Patel¹,

Perry²

2019

Clinical Ophthalmic Oncology

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Modified Enucleation for Choroidal Melanoma with Large Extrascleral Extension

Cited by 4 publications

References 18 publications

Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration

Large Hemorrhagic Extrascleral Ciliary Body Melanoma Recurrence Treated With Transarterial Embolization and Coiling Followed by Exenteration

Magnetic Resonance Imaging in the Clinical Care for Uveal Melanoma Patients—A Systematic Review from an Ophthalmic Perspective

Enucleation for Ocular Tumors

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