Modified extrusion-spheronization as a technique of microencapsulation for stabilization of choline bitartrate using hydrogenated soya bean oil

Abstract

Introduction:Choline bitartrate (CBT) is a vital nutrient for fetal brain development and memory function. It is hygroscopic in nature which is associated with stability related problem during storage such as development of fishy odor and discoloration.Aim:Microencapsulation method was adopted to resolve the stability problem and for this hydrogenated soya bean oil (HSO) was used as encapsulating agent.Materials and Methods:Industrially feasible modified extrusion-spheronization technique was selected for microencapsulation. HSO was used as encapsulating agent, hydroxypropyl methyl cellulose E5/E15 as binder and microcrystalline cellulose as spheronization aid. Formulated pellets were evaluated for parameters such as flow property, morphological characteristics, hardness-friability index (HFI), drug content, encapsulation efficiency, and in vitro drug release. The optimized formulations were also characterized for particle size (by laser diffractometry), differential scanning calorimetry, powder X-ray diffractometry (PXRD), Fourier transform infrared spectroscopy, and scanning electron microscopy.Results and Discussions:The results from the study showed that coating of 90% and 60% CBT was successful with respect to all desired evaluation parameters. Optimized formulation was kept for 6 months stability study as per ICH guidelines, and there was no change in color, moisture content, drug content, and no fishy odor was observed.Conclusion:Microencapsulated pellets of CBT using HSO as encapsulating agent were developed using modified extrusion spheronization technique. Optimized formulations, CBT 90% (F5), and CBT 60% (F10), were found to be stable for 4M and 6M, respectively, at accelerated conditions.

Choline supplements: An update

“…Choline bitartrate is widely used in dietary supplements. One of the main advantage of bitartrate is its lower hygroscopicity ( 89 ), a feature that in the last years has triggered an increase of its use. The methyl donor betaine, a choline derivative, has been shown to facilitate the cytosolic re-methylation of homocysteine to methionine in a reaction catalyzed by the enzyme betaine-homocysteine S-methyltransferase (BHMT).…”

Formulation and Characterization of Rice Bran Oil in Alginate Microcapsules

“…4,5 Microencapsulation is a technology to create a thin film round over the core particle to subtract the core interaction with uncertain environment and obviates chemical reaction. 6 This is an effective tactic to resist the environment situation. Many techniques have been constructed to shape microgel of oil microcapsules, for example, extruction, melt injection, and spray drying.…”