Modified Highland Barley Regulates Lipid Metabolism and Liver Injury in High Fat and Cholesterol Diet ICR Mice

Zhou, Jinfeng; Wu, Leiyan

doi:10.3390/foods11244067

Cited by 10 publications

(4 citation statements)

References 43 publications

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“…Te above active ingredients have been found to have lipid-lowering, antioxidant, and other efects in recent years [11][12][13]. In addition, after microwaving, baking, and heat fuidization, treated highland barley dietary fber displayed a higher antioxidant activity, β-glucan extractability, and improved liver injury of obese mice [14]. Te above research indicates that the dietary fber in highland barley is a potential cash crop.…”

Section: Introductionmentioning

confidence: 90%

T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

Yang

Ma²,

Han³

et al. 2023

Journal of Food Biochemistry

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The role of dietary fiber in highland barley in lowering blood lipids has been continuously studied in recent years. However, its effects on diabetes and diabetic nephropathy are rarely studied. Considering that highland barley bran is rich in dietary fiber, the effective use of dietary fiber in highland barley bran can not only alleviate the symptoms of diabetes but also improve the local economy. This article aimed to study the effects of highland barley fiber-rich powder (T-fiber) with a high-quality natural dietary fiber ratio (insoluble fiber/soluble fiber = 3 : 1) on the symptoms of hyperglycemia in a diabetic mouse model. Compared with the model group’s blood glucose level (30.80 mmol/L), glucose tolerance (28.57 mmol/L), and glycosylated serum protein (2.43 mmol/L), T-fiber presented significant reductions in blood glucose (23.69 mmol/L), better glucose tolerance (21.32 mmol/L), and glycosylated serum protein (1.78 mmol/L) in the diabetic mouse model. Meanwhile, T-fiber effectively alleviated hepatocellular lesions. In addition, T-fiber not only improved kidney function by reducing the 24-hour urine output (8.25 ml), urine protein levels (11.51 mg), and serum creatinine (13.80 μmol/L) but also alleviated renal pathology, including glomerular hypertrophy, mesangial expansion, and fibrosis. The above results proved the ability of T-fiber to reduce blood glucose and alleviate liver and renal function in diabetic mice. Altogether, T-fiber is a capable formula for utilizing highland barley bran dietary fiber, which alleviates diabetes symptoms and endows highland barley with promising value.

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Section: Introductionmentioning

confidence: 90%

T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

Yang

Ma²,

Han³

et al. 2023

Journal of Food Biochemistry

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“…We then carefully examined each article to ensure that they met our criteria, including full access to the article, a control and experiment group, complete data, and lipid profile parameters. As a result, we identified seven articles that met our requirements and provided us with 11 studies code [5,6,12,13,14,15,16] for analysis using CMA software. The process of data review in this research is shown in Figure 1.…”

Section: Study Characteristicmentioning

confidence: 99%

The Effect of Fiber Intake on Blood Lipid Profile: A Mini Meta-analysis

Ridwan,

Palupi,

Setiawan

2024

IOP Conf. Ser.: Earth Environ. Sci.

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Regulation of blood lipid profiles is significantly influenced by fiber. Consuming enough fiber can help to keep blood lipid profile within normal range, which in turn reduces the risk of heart disease. To synthesize the effect size ofs fiber intake on lipid profiles, a mini meta-analysis was conducted using Hedges’g method. Comprehensive Meta-analysis was used to analyze eleven studies that were coded for this purpose. The analysis findings indicated that dietary fiber consumption significantly reduces TC, LDL, and TG levels with cumulative effect-size were (±95% confidence interval) −1.38±1.21; −1.16±1.16; −0.53±0.65 respectively. At HDL levels, cumulative effect-size value was 0.83±0.94, so fiber consumption significantly increases HDL levels. The Egger regression and Begg rank correlation analysis found evidence of publication bias, with a p-value of less than 0.001. In conclusion, it can be stated that fiber intake may prevent dyslipidemia, which is a possible pathway to several non-communicable diseases.

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“…Their mutations (i.e., Niemann–Pick type C disease) lead to massive lysosomal accumulation of cholesterol and sphingolipids (Wanikawa et al., 2020 ). Consequently, HFD enrichment with 1% cholesterol is enough to enhance lipid storage and inflammation in liver of HFD obese mice compared with animals fed with a chow diet (Chang et al., 2021 ; Zhou & Wu, 2022 ). Indeed, HFD impair lysosomal function and autophagic flux (Yamamoto et al., 2017 ).…”

Section: How High‐fat Diets Affect Extracellular Vesicle Lipid Compos...mentioning

confidence: 99%

High‐fat diets: You are what you eat….your extracellular vesicles too!

Rome,

Tacconi

2023

J of Extracellular Vesicle

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Recent works indicate that the lipid composition of extracellular vesicles (EVs) can modify their biological functions and their incorporation into recipient cells. In particular high‐fat diets affect EV biogenesis, EV lipid composition, EV targeting and consequently the cross‐talk between tissues. This review connects different research topics to show that a vicious circle is established during the development of high‐fat diet‐induced obesity, connecting the alteration of lipid metabolism, the composition of extracellular vesicles and the spread of deleterious lipids between tissues, which participates in NAFLD/NASH and diabetes development. According to the studies described in this review, it is urgent to take an interest in this question as the modulation of EV lipid composition could be an important factor to take into account during the therapeutic management of patients suffering from metabolic syndrome and related pathologies such as obesity and diabetes. Furthermore, as lipid modification of EVs is a strategy currently being tested to enable better integration into their target tissue or cell, it is important to consider the impact of these lipid modifications on the homeostasis of these targets.

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Modified Highland Barley Regulates Lipid Metabolism and Liver Injury in High Fat and Cholesterol Diet ICR Mice

Cited by 10 publications

References 43 publications

T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

The Effect of Fiber Intake on Blood Lipid Profile: A Mini Meta-analysis

High‐fat diets: You are what you eat….your extracellular vesicles too!

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