Modified host defence peptide GF19 slows TNT-mediated spread of corneal herpes simplex virus serotype I infection
Neethi C. Thathapudi,
Natalia Callai-Silva,
Kamal Malhotra
et al.
Abstract:Corneal HSV-1 infections are a leading cause of infectious blindness globally by triggering tissue damage due to the intense inflammation. HSV-1 infections are treated mainly with antiviral drugs that clear the infections but are inefficient as prophylactics. The body produces innate cationic host defence peptides (cHDP), such as the cathelicidin LL37. Various epithelia, including the corneal epithelium, express LL37. cHDPs can cause disintegration of pathogen membranes, stimulate chemokine production, and att… Show more
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