Modified katira gum for colon targeted drug delivery

Abstract

The aim of the this study is to develop colon targeted drug delivery systems for Ibuprofen using grafted katira gum as a carrier. Polyacrylamide-grafted katira gum was synthesized by grafting acrylamide onto katira gum in presence of varying concentration of ceric ammonium nitrate (CAN) as initiator. Elemental analysis, FTIR, TGA, DTA, DSC, and SEM were used to characterize the grafting of acrylamide onto katira gum. Matrix tablets containing various proportions of grafted katira gum were prepared by wet granulation method. All the formulations were evaluated for hardness, drug content, swelling index, and in vitro release studies in simulated gastric fluid, small intestinal fluid, and simulated colonic fluid with and without enzymes. Ibuprofen was used for controlled release study. The drug release mechanism was studied by fitting into Peppas model and was found to be supercase-II transport. Matrix tablets containing 0.3 g of CAN/gm of acrylamide showed optimum value and retained its physical integrity in simulated gastric, small intestinal and colonic fluid, where as other composition disintegrated within 2 h of dissolution testing in pH 1.2 buffer, simulated gastric fluid. The results of this study indicates that Ibuprofen matrix tablet containing 60 wt % composition of the above grafted katira gum would be potential formulations in delivering the drug to the colon and the more susceptible for enzymatic degradation.

Evaluation of Gum Katira as a Model Sustained Release Adjuvant in the Preparation of Etodolac Loaded Microsphere.

“…D455001482, Shimadzu corp, Japan) after removing the excess surface water using tissue paper. The same process was repeated for 12 …”

“…These types of curves are generally exhibited by Non-Newtonian system such as polymeric solution of sodium alginate. 34 The rheogram of Gum Katira(1% w/v, 2% w/v) and sodium alginate (1%w/v) solution at different time interval (12 th and 24 th hrs) are graphically presented in (Figure 3). The rheograms of aqueous dispersion of both gums indicate pseudoplastic flow.…”

“…11 Gum Katira was selected as the matrix forming material because of its well-established biocompatibility, non toxic and safe material for the use in food and pharmaceutical industries. 12 Gum Katira is a novel heteropolysaccharide isolated from Cochlospermum religiosum and consists of D-galactose, D-galactouronic acid and L-rhamnose in a molecular ratio 2:1:3 respectively together with traces of a ketohexose. 13 This gum is pale, semi transparent and swells to form a pasty transparent mass with water.…”

Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery

“…Other grafting and crosslinking with natural polymers include polyacrylamide grafted to katira gum and katira gum crosslinked with glutaraldehyde [30,31]; crosslinking of guar gum with trisodiumtrimetaphosphate [32]; cashew gum crosslinked with epichlorohydrin [33]. Figure 2.…”

Development and Evaluation of Ca+ 2 Ion Cross-Linked Carboxymethyl Xanthan Gum Tablet Prepared by Wet Granulation Technique

“…), chemical cross-linking (with glutaraldehyde, epichlorhydrin), and ionic cross-linking (with Ca +2 , Ba +2 , Al +3 ions), offers many new functional properties to meet their needs in design of drug delivery system (3). Several polysaccharides such as alginate (4,5), guar gum (6, 7), katira gum (8), tamarind gum (9), and pectin (10,11) have been derivatized and/or cross-linked to have tailor-made products of various types for drug delivery devices.…”