Modified lipoproteins in periodontitis: a link to cardiovascular disease?

Ljunggren, Stefan; Bengtsson, Torbjörn; Karlsson, Helén; Johansson, Carin Starkhammar; Palm, Eleonor; Nayeri, Fariba; Ghafouri, Bijar; Davies, Julia R.; Svensäter, Gunnel; Lönn, Johanna

doi:10.1042/bsr20181665

Cited by 25 publications

(21 citation statements)

References 72 publications

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“…Serum Paraoxonase/Arylesterase 1 (PON1) activity was measured in plasma as previously described [ 28 ]. Briefly, lithium heparin plasma was diluted 1:80 with a salt buffer (20 mM Tris–HCl and 1.0 mM CaCl 2 ) and a triplicate of 20 μl diluted plasma were added to the wells in a UV-transparent 96-well plate (Sigma–Aldrich).…”

Section: Methodsmentioning

confidence: 99%

Metal additive manufacturing and possible clinical markers for the monitoring of exposure-related health effects

et al. 2021

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Additive manufacturing (AM) includes a series of techniques used to create products, in several different materials, such as metal, polymer or ceramics, with digital models. The main advantage of AM is that it allows the creation of complex structures, but AM promises several additional advantages including the possibility to manufacture on demand or replacing smaller worn parts by directly building on an existing piece. Therefore, the interest for and establishment of AM is rapidly expanding, which is positive, however it is important to be aware that new techniques may also result in new challenges regarding health and safety issues. Metals in blood and possible clinical effects due to metal exposure were investigated in AM operators at one of the first serial producing AM facilities in the world during two consecutive years with implementation of preventive measures in-between. As comparison, welders and office workers as control group were investigated. Health investigations comprised of surveys, lung function tests, antioxidant activity and vascular inflammation as well as renal- and hepatic function analysis. AM operators had significantly reduced nickel levels in blood (10.8 vs 6.2 nmol/L) as well as improved lung function (80 vs 92% of predicted) from year 1 to year 2. This is in line with previously published results displaying reduced exposure. Blood cobalt and nickel levels correlated with previously reported urinary levels, while blood chromium did not. Multivariate modelling showed that blood cobalt, antioxidant/inflammatory marker serum amyloid A1/serum paraoxonase/arylesterase 1 activity and the hepatic markers aspartate transaminase, alanine transaminase, and alkaline phosphatase were higher in AM operators compared to controls. The study show that the selected clinical analyses could function as a complement to metal analyses in biological fluids when investigating exposure-related health effects in AM operators. However, validation in larger cohorts is necessary before more definite conclusions could be drawn.

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Section: Methodsmentioning

confidence: 99%

Metal additive manufacturing and possible clinical markers for the monitoring of exposure-related health effects

et al. 2021

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“…Also crosssectional studies have reported that vitamin D deficiency is associated with increased risk of CVD and mortality [19,20]. Elevations of serum lipids and low serum levels of 25-hydroxyvitamin D may have a serious negative impact on periodontal and cardiovascular health [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Relationship between risk markers for cardiovascular disease and peri-implant diseases

Ustaoğlu

Erdal

2020

Int J Implant Dent

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Background The aim of this paper is to explore the serum biochemical parameters also known as risk markers for cardiovascular system, in individuals who have received dental implant treatment, and to reveal risk factors for peri-implant diseases. Methods The study included 58 subjects with peri-implantitis, 49 subjects with peri-implant mucositis, and 49 healthy subjects. All the subjects were assessed in terms of both peri-implant clinical parameters—probing depth (PD), bleeding on probing (BOP), the type of prosthesis, gingival index (GI), keratinized mucosa width (KMW), and plaque index (PI)—and serum biochemical parameters (e.g., LDL cholesterol, HDL cholesterol, triglyceride, total cholesterol, vitamin D, uric acid, white blood cell (WBC), neutrophil, hemoglobin (Hb), and platelet counts). Results KMW was the lowest in the peri-implantitis group. Compared with the other groups, the peri-implantitis group showed significantly higher levels of triglyceride, uric acid, and WBC. The peri-implantitis group had the lowest level of vitamin D. Triglyceride and uric acid levels had positive correlations with peri-implant clinical parameters. Conclusion High levels of triglyceride and uric acid may pose a risk for both peri-implant diseases and cardiovascular diseases. Prior to dental implant surgery, patients’ serum biochemical parameters should be checked.

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“…Both APOA1 and APOA2 were found to be significantly downregulated in G1–C and G1–G2 comparisons. While their role in periodontitis is recently investigated [ 51 ], their possible association with caries susceptibility has yet to be explored.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

et al. 2021

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Saliva, an essential oral secretion involved in protecting the oral cavity’s hard and soft tissues, is readily available and straightforward to collect. Recent studies have analyzed the salivary proteome in children and adolescents with extensive carious lesions to identify diagnostic and prognostic biomarkers. The current study aimed to investigate saliva’s diagnostic ability through proteomics to detect the potential differential expression of proteins specific for the occurrence of carious lesions. For this study, we performed bioinformatics and functional analysis of proteomic datasets, previously examined by our group, from samples of adolescents with regulated and unregulated type 1 diabetes, as they compare with healthy controls. Among the differentially expressed proteins relevant to caries pathology, alpha-amylase 2B, beta-defensin 4A, BPI fold containing family B member 2, protein S100-A7, mucin 5B, statherin, salivary proline-rich protein 2, and interleukin 36 gamma were significantly downregulated in poorly-controlled patients compared to healthy subjects. In addition, significant biological pathways (defense response to the bacterium, beta-defensin activity, proline-rich protein activity, oxygen binding, calcium binding, and glycosylation) were deregulated in this comparison, highlighting specific molecular characteristics in the cariogenic process. This analysis contributes to a better understanding of the mechanisms involved in caries vulnerability in adolescents with unregulated diabetes.

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Modified lipoproteins in periodontitis: a link to cardiovascular disease?

Cited by 25 publications

References 72 publications

Metal additive manufacturing and possible clinical markers for the monitoring of exposure-related health effects

Metal additive manufacturing and possible clinical markers for the monitoring of exposure-related health effects

Relationship between risk markers for cardiovascular disease and peri-implant diseases

Downregulation of Salivary Proteins, Protective against Dental Caries, in Type 1 Diabetes

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