Modified mesoporous silica nanoparticles coated by polymer complex as novel curcumin delivery carriers

Szegedi, Ágnes; Shestakova, Pavletta; Trendafilova, Ivalina; Mihayi, Judith; Tsacheva, Ivelina; Mitova, Violeta; Kyulavska, Mariya; Koseva, Neli; Momekova, Denitsa; Konstantinov, Spiro; Aleksandrov, Hristiyan A.; Petkov, Petko St.; Koleva, Iskra Z.; Vayssilov, Georgi N.; Popova, Margarita

doi:10.1016/j.jddst.2018.12.016

Cited by 30 publications

(21 citation statements)

References 53 publications

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“…MSNs Aptamer-functionalized Curcumin 3.4 [194] MSNs Amine-functionalized and chitosan-coated Gallic acid Up to 58 [195] KIT-6 Guanidine-functionalized and PEGylated Curcumin 50 [196] KIT-6 and KIL-2 Amino-modified Curcumin 5-28 [197] MSNs…”

Section: Msn Type Surface Modification Natural Cargo Loading Content mentioning

confidence: 99%

“…As an interesting nanoplatform, the fabricated lipid bilayer-coated curcumin-based MSNs unveiled a controllable and highly biocompatible theranostic nanosystem for cancer delivery [321]. Another recent strategy for building a delivery system for curcumin is by loading the prodrug into amino-MSNs using APTES silanes (KIL-2 and KIT-6), then coated by polyelectrolyte polymer complex by means of the layer-by-layer technique [197]. Based on the comparative data from this study, the nanoformulation exerts an anticancer effect on human cell lines, namely HL-60, EJ, and HEK-293, compared to free curcumin, demonstrating the promising delivery of prodrug with a sustained release effect.…”

Section: Curcuminmentioning

confidence: 99%

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Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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Natural prodrugs derived from different natural origins (e.g., medicinal plants, microbes, animals) have a long history in traditional medicine. They exhibit a broad range of pharmacological activities, including anticancer effects in vitro and in vivo. They have potential as safe, cost-effective treatments with few side effects, but are lacking in solubility, bioavailability, specific targeting and have short half-lives. These are barriers to clinical application. Nanomedicine has the potential to offer solutions to circumvent these limitations and allow the use of natural pro-drugs in cancer therapy. Mesoporous silica nanoparticles (MSNs) of various morphology have attracted considerable attention in the search for targeted drug delivery systems. MSNs are characterized by chemical stability, easy synthesis and functionalization, large surface area, tunable pore sizes and volumes, good biocompatibility, controlled drug release under different conditions, and high drug-loading capacity, enabling multifunctional purposes. In vivo pre-clinical evaluations, a significant majority of results indicate the safety profile of MSNs if they are synthesized in an optimized way. Here, we present an overview of synthesis methods, possible surface functionalization, cellular uptake, biodistribution, toxicity, loading strategies, delivery designs with controlled release, and cancer targeting and discuss the future of anticancer nanotechnology-based natural prodrug delivery systems.

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Section: Msn Type Surface Modification Natural Cargo Loading Content mentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

AbouAitah

Łojkowski

2021

Pharmaceutics

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“…In Figure 5 characteristic CD bands at 1028 cm −1 and at 1081 and 1155 cm −1 are present. The former corresponds to C-O-C stretching (νC-O-C) of glucose ring and glycosidic bonds, while the latter two bands belong to C-O stretching vibrations (νC-O) of −C−OH moieties [ 46 , 47 ]. It is worth to note, that in the spectra of poly-CD samples the intensity of the bands at 1155 cm −1 is reduced.…”

Section: Resultsmentioning

confidence: 99%

Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

et al. 2020

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The limited bioavailability of the highly hydrophobic natural compound, curcumin with wide range of beneficial bioactivity is still a challenge. Self-association type systems of polyethylene oxide-polypropylene oxide-polyethylene oxide block copolymers (Pluronic) were applied to enhance the aqueous solubility of curcumin. Comparison of four Pluronics (94, 105, 127,108) with different compositions led to the conclusion that solubilization capacity is maximum for Pluronic 105 with intermediate polarity (hydrophilic/lipophilic balance (HLB) = 15) possessing the optimum balance between capacity of hydrophobic core of the micelle and hydrophilic stabilizing shell of the associate. Curcumin concentration in aqueous solution was managed to increase 105 times up to 1–3 g/L applying Pluronic at 0.01 mol/L. Formation of a host–guest complex of cyclodextrin as another way of increasing the curcumin solubility was also tested. Comparing the(2-hydroxypropyl)-α, β and γ cyclodextrins (CD) with 6, 7 and 8 sugar units and their polymers (poly-α-CD, poly-β-CD, poly-γ-CD) the γ-CD with the largest cavity found to be the most effective in curcumin encapsulation approaching the g/L range of concentration. The polymer type of the CDs presented prolonged and pH dependent release of curcumin in the gastrointestinal (GI) system modelled by simulated liquids. This retarding effect of polyCD was also shown and can be used for tuning in the combined system of Pluronic micelle and polyCD where the curcumin release was slower than from the micelle.

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“…The solid-sate reaction method generally utilizes a ball mill to mix the drug with mesoporous particles on the basis of the interaction between drugs and the silanol groups on the surface of the particles. Although this method was not able to ensure the complete adsorption of drugs in the pores, recent work reported that the solid-state method was more efficient for curcumin loading and amorphization in the pores than the incipient wetness impregnation method as one of the solvent methods [ 64 ].…”

Section: Emerging Pharmaceutical Techniques For Amorphization Of Poorly Water-soluble Drugsmentioning

confidence: 99%

“…The solvent is then removed by filtration, and the drug-loaded mesoporous particles are further washed several times to eliminate excess drug which could be adsorbed on the surface instead of the pores of the mesoporous particles. Additionally, thermogravimetric analysis can be used to differentiate the drug adsorbed within the pores and on the surface of mesoporous particles by comparing their transition profiles [ 64 , 67 ].…”

Section: Emerging Pharmaceutical Techniques For Amorphization Of Poorly Water-soluble Drugsmentioning

confidence: 99%

Recent Technologies for Amorphization of Poorly Water-Soluble Drugs

Kim

Tin

et al. 2021

Pharmaceutics

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Amorphization technology has been the subject of continuous attention in the pharmaceutical industry, as a means to enhance the solubility of poorly water-soluble drugs. Being in a high energy state, amorphous formulations generally display significantly increased apparent solubility as compared to their crystalline counterparts, which may allow them to generate a supersaturated state in the gastrointestinal tract and in turn, improve the bioavailability. Conventionally, hydrophilic polymers have been used as carriers, in which the amorphous drugs were dispersed and stabilized to form polymeric amorphous solid dispersions. However, the technique had its limitations, some of which include the need for a large number of carriers, the tendency to recrystallize during storage, and the possibility of thermal decomposition of the drug during preparation. Therefore, emerging amorphization technologies have focused on the investigation of novel amorphous-stabilizing carriers and preparation methods that can improve the drug loading and the degree of amorphization. This review highlights the recent pharmaceutical approaches utilizing drug amorphization, such as co-amorphous systems, mesoporous particle-based techniques, and in situ amorphization. Recent updates on these technologies in the last five years are discussed with a focus on their characteristics and commercial potential.

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Modified mesoporous silica nanoparticles coated by polymer complex as novel curcumin delivery carriers

Cited by 30 publications

References 53 publications

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Delivery of Natural Agents by Means of Mesoporous Silica Nanospheres as a Promising Anticancer Strategy

Highly Enhanced Curcumin Delivery Applying Association Type Nanostructures of Block Copolymers, Cyclodextrins and Polycyclodextrins

Recent Technologies for Amorphization of Poorly Water-Soluble Drugs

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