Modified open-ended dielectric probe in distinction between cancer and healthy breast tissues

Rudowski, Marek; Orzechowski, Kazimierz; Rząca, Marek

doi:10.1016/j.jnoncrysol.2009.06.054

Cited by 4 publications

(7 citation statements)

References 8 publications

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“…The close similarity between the images and dielectric maps are ex- plicitly visible. This study as well as earlier publications [19,20] demonstrate multiple tests that have confirmed a correct differentiation between healthy and neoplastic tissue.…”

Section: Methodssupporting

confidence: 85%

“…The physics back- ground of the measurements and the tests carried out on reference substances and animal tissue have been described in earlier publications from physics journals [18][19][20].…”

Section: Methodsmentioning

confidence: 99%

“…Laboratory testing has demonstrated that cancer tissue can be detected both on the surface of a specimen as well as underneath a 1-2 mm layer of healthy breast tissue [18,19].…”

Section: Methodsmentioning

confidence: 99%

“…Laboratory testing has demonstrated such differences in clean and dried samples [17][18][19], however in real-life situations the presence of blood and serum interferes with such measurements by apparently increasing the permittivity and conductivity in normal tissue to those levels found in malignant tissue. For this reason the method is problematic for use during surgery [21,22].…”

Section: Introductionmentioning

confidence: 99%

“…This study demonstrates the use of a probe with socalled blocked electrodes, where the electric sensor does not come into direct contact with the examined tissue but is separated by a thin layer of insulation (polyethylene film) [18][19][20] thus avoiding the conflicting interference from blood and serum. The insulating polyethylene between the probe and sample ensures sterility of the field of operation, thus allowing multiple uses of the same probe.…”

Section: Introductionmentioning

confidence: 99%

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Dielectric-technique-assisted breast cancer surgery

Rząca¹,

Orzechowski²,

Wolny³

et al. 2017

Nowotwory. Journal of Oncology

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Introduction. In conservative breast cancer surgery, removing all carcinogenic lesions is a sound basis for achieving therapeutic success. The cleanness of the cutting margin is usually assessed after surgery and any residual cancerous tissue that are found, require further surgery. A simple and cheap assessment method is presented which can be used during surgery, the dielectric cancer probe (DCP), which allows the surgeon to take fast decisions on whether to extend incisions. Method. The DCP method consists of measuring and then differentiating between the electrical properties (permeability and conductivity) of healthy and cancerous breast tissue. A polyethylene strip is used to separate the examined tissue from the instrument probe and the procedure is carried out by the operating surgeon. Results. This method was found to allow correct identification of cancerous breast tissue based on taking 189 samples from 70 patients using the intraoperative hand probe. The sensitivity and specificity were respectively 87% and 99%. Conclusions. The DCP is a high sensitivity method and is totally safe for the patient and can be used intraoperatively. The device is an aid to the surgeon for differentiating between healthy and cancerous breast tissue. Its widespread use should reduce the number of reoperations in the conservative surgical management of breast cancer patients. NOWOTWORY J Oncol 2017; 67, 2: 108-114

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Section: Methodssupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

“…Laboratory testing has demonstrated that cancer tissue can be detected both on the surface of a specimen as well as underneath a 1-2 mm layer of healthy breast tissue [18,19].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dielectric-technique-assisted breast cancer surgery

Rząca¹,

Orzechowski²,

Wolny³

et al. 2017

Nowotwory. Journal of Oncology

Self Cite

View full text Add to dashboard Cite

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Measurements of electric properties using an open-ended probe blocked by a non-conducting foil

2016

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Co-integrated microfluidic and THz functions for biochip devices

Laurette

Treizebré

Bocquet

2011

J. Micromech. Microeng.

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TeraHertz (THz) spectroscopy is becoming an alternative way to probe biological interactions in real-time conditions. However, accurate and reproducible THz measurements of aqueous solutions, largely represented in life sciences, remain difficult. A THz microsystem which couples both electromagnetic and microfluidic integrated functions is presented here. Its technological process is accurately detailed and enables easy designs of advanced THz and microfluidic functions. It is composed of the deposition of gold wires on a glass wafer to guide the THz waves. Then, a whole silicon wafer is bonded by using a thermosensitive-polymer thermo-compression. Silicon is deep-etched to create the microchannels which are finally covered with a second glass wafer. This bonding–etching process enables huge freedom and independence for electromagnetic and microfluidic designs. The technological process characterization has shown that the manufactured biochip is compatible with pressures up to 37 bar. First measurements with empty and water-filled channels have been carried out and have shown the ability to perform THz spectroscopy inside the chip. Then, first measurements on proteins have been performed and shown the system ability to probe protein concentration. This kind of microfluidic microsystem, allowing complex design for integrated electronic and microfluidic circuits, defines a true new instrumental way for life science investigations.

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Modified open-ended dielectric probe in distinction between cancer and healthy breast tissues

Cited by 4 publications

References 8 publications

Dielectric-technique-assisted breast cancer surgery

Dielectric-technique-assisted breast cancer surgery

Measurements of electric properties using an open-ended probe blocked by a non-conducting foil

Co-integrated microfluidic and THz functions for biochip devices

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