Modified Polysaccharides as Drug Delivery

Efthimiadou, Eleni K.; Metaxa, Aikaterini-Foteini; Κορδάς, Γ.

doi:10.1007/978-3-319-03751-6_23-1

Cited by 7 publications

(1 citation statement)

References 99 publications

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“…The alginates are easily rinsed with sterile saline water, making dressing removal painless and not interfering with healing granulation. These dressings are very useful for the treatment of moderate to heavily exudating wounds 22 . For the treatment of wound infection due to E. coli crossed linked hyaluronic acid hydrogel complexed with Ethylene diamine tetraacetic acid-Fe 3+ is used.…”

Section: Wound Healingmentioning

confidence: 99%

Untitled

2022

IJPSR

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Polysaccharides are composed of monosaccharide's linked by glycosidic bonds. These are abundantly available and are obtained from renewable resources. Polysaccharides provide an array of primary structures and conformations used in the pharmaceutical industry. Natural polysaccharides properties can be substantially modulated by chemical, physical, and enzymatic modifications and have received increased attention to expanding the landscape of application of polysaccharides in diverse sectors. Modifying the natural polysaccharides properties and structures gives functionally improved polysaccharides with excellent bioavailability, biocompatibility, structural stability, and versatile chemical. By modifying the physicochemical properties of polysaccharides, systems like micelles, hydrogels, liposomes, niosomes and vesicles are produced. The modified polysaccharides have a remarkable application in gene delivery, targeted cancer therapy, delivery of the drug, wound dressings, tissue engineering, nanocarriers, biosensors, pharmaceutical formulations, agricultural applications, and food industry. This article covers different types of polysaccharides and distinct methodologies applied during the new modified synthesis of polysaccharides and also the study of their properties after modification. This review also highlights the application of these modified polysaccharides in various pharmaceutical, biomedical and allied fields. INTRODUCTION:Polysaccharides are ideal resources obtained naturally used in supplements and pharmaceuticals, which received increasing consideration in the last many years. These polysaccharides have essential in pharmaceutical sciences. Due to this, there is a growing interest in their synthesis, modification, characterization, and application 1 .

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Section: Wound Healingmentioning

confidence: 99%

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2022

IJPSR

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Microbial Biopolymers and Their Derivatives as Nanotechnological Tools for Medicine

Marcelino¹,

Gonçalves²,

Aizawa³

et al. 2021

Nanotechnology in Medicine

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Unique vesicular nano‐architecture of thiobarbiturate derived chitosan with excellent hydrophilicity

Mandal

Mukherjee

Patra

et al. 2021

Journal of Polymer Science

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The natural polymer chitosan is conjugated with hydrophilic thiobarbiturate entity which makes the whole molecule amphiphilic as well as water‐soluble. The water solubility of this molecule leads to an interesting supramolecular architecture via self‐assembly. The monomers are synthesized via Friedel Crafts alkylation and ring‐closing reaction where homopolymers derivatives undergo coupling and thiol‐ene click reaction. The monomer and the modified polymers are well characterized through conventional spectroscopic techniques. The self‐assembly behavior is then confirmed through critical aggregation concentration study and dynamic light scattering. The field emission scanning electron microscope and transmission electron microscope images provide the architectures' fascinating morphology. Finally, the loading and release of doxorubicin drug are performed to investigate the biomedical applications.

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Modified Polysaccharides as Drug Delivery

Cited by 7 publications

References 99 publications

Untitled

Untitled

Microbial Biopolymers and Their Derivatives as Nanotechnological Tools for Medicine

Unique vesicular nano‐architecture of thiobarbiturate derived chitosan with excellent hydrophilicity

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