Modified Polysaccharides for Drug Delivery

Efthimiadou, Eleni K.; Metaxa, Aikaterini-Foteini; Κορδάς, Γ.

doi:10.1007/978-3-319-16298-0_23

Cited by 15 publications

(6 citation statements)

References 98 publications

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“…Starch is a polysaccharide of glucose composed of α-amylose and amylopectin polymers and it is one of the most used excipients in pharmacology [39][40][41]. The melting temperature depends on the ratio of α-amylose/amylopectin, Mw and water content and, in the native dry form of the starch, it exceeds the degradation temperature, making it not appropriate to be processed by thermomechanical techniques [42,43].…”

Section: Discussionmentioning

confidence: 99%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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Three-dimensional printed drug development is nowadays an active area in the pharmaceutical industry, where the search for an appropriate edible carrier that permits the thermal processing of the mixture at temperature levels that are safe for the drug is an important field of study. Here, potato starch and hydroxypropyl cellulose based mixtures loaded with paracetamol up to 50% in weight were processed by hot melt extrusion at 85 °C to test their suitability to be thermally processed. The extruded mixtures were tested by liquid chromatography to analyze their release curves and were thermally characterized. The drug recovery was observed to be highly dependent on the initial moisture level of the mixture, the samples being prepared with an addition of water at a ratio of 3% in weight proportional to the starch amount, highly soluble and easy to extrude. The release curves showed a slow and steady drug liberation compared to a commercially available paracetamol tablet, reaching the 100% of recovery at 60 min. The samples aged for 6 weeks showed slower drug release curves compared to fresh samples, this effect being attributable to the loss of moisture. The paracetamol loaded mixture in powder form was used to print pills with different sizes and geometries in a fused deposition modelling three-dimensional printer modified with a commercially available powder extrusion head, showing the potential of this formulation for use in personalized medicine.

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Section: Discussionmentioning

confidence: 99%

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Mendibil

Tena

Duque³

et al. 2021

Pharmaceutics

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“…Different seaweed polysaccharides have their own merits and applications. Ulvan is an anionic polysaccharide and thus easily forms NPs with cationic polymers such as chitosan, which indicates its potential as a biocompatible drug delivery carrier [ 198 , 199 , 200 , 201 ].…”

Section: Future Research In Seaweed Polysaccharide Npsmentioning

confidence: 99%

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

et al. 2016

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Abstract:In recent years, there have been major advances and increasing amounts of research on the utilization of natural polymeric materials as drug delivery vehicles due to their biocompatibility and biodegradability. Seaweed polysaccharides are abundant resources and have been extensively studied for several biological, biomedical, and functional food applications. The exploration of seaweed polysaccharides for drug delivery applications is still in its infancy. Alginate, carrageenan, fucoidan, ulvan, and laminarin are polysaccharides commonly isolated from seaweed. These natural polymers can be converted into nanoparticles (NPs) by different types of methods, such as ionic gelation, emulsion, and polyelectrolyte complexing. Ionic gelation and polyelectrolyte complexing are commonly employed by adding cationic molecules to these anionic polymers to produce NPs of a desired shape, size, and charge. In the present review, we have discussed the preparation of seaweed polysaccharide-based NPs using different types of methods as well as their usage as carriers for the delivery of various therapeutic molecules (e.g., proteins, peptides, anti-cancer drugs, and antibiotics). Seaweed polysaccharide-based NPs exhibit suitable particle size, high drug encapsulation, and sustained drug release with high biocompatibility, thereby demonstrating their high potential for safe and efficient drug delivery.

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“…By utilizing EPSs, the body would be capable of naturally breaking down the biopolymer-derived drug delivery vehicle once the transfer of the drug is complete. Polysaccharide structures undergo degradation via the lysozyme, an antimicrobial combatant that cleaves the peptidoglycan portion of cell walls [ 7 , 8 ]. The strong similarities the biochemical properties of polysaccharides share with the extracellular matrices in humans help lysozymes recognize the carbohydrate polymers [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

5-Fluorouracil-Encapsulated Films Using Exopolysaccharides from a Thermophilic Bacterium Geobacillus sp. WSUCF1 for Topical Drug Delivery

Laubach

Sani

2023

Micromachines

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Bacteria are capable of producing a specific type of biopolymer, termed exopolysaccharides (EPSs). EPSs from thermophile Geobacillus sp. strain WSUCF1 specifically can be assembled using cost-effective lignocellulosic biomass as the primary carbon substrate in lieu of traditional sugars. 5-fluorouracil (5-FU) is an FDA-approved, versatile chemotherapeutic that has yielded high efficacy against colon, rectum, and breast cancers. The present study investigates the feasibility of a 5% 5-fluorouracil film using thermophilic exopolysaccharides as the foundation in conjunction with a simple self-forming method. The drug-loaded film formulation was seen to be highly effective against A375 human malignant melanoma at its current concentration with viability of A375 dropping to 12% after six hours of treatment. A drug release profile revealed a slight burst release before it settled into an extended and maintained release of 5-FU. These initial findings provide evidence for the versatility of thermophilic exopolysaccharides produced from lignocellulosic biomass to act as a chemotherapeutic-delivering device and expand the overall applications of extremophilic EPSs.

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Modified Polysaccharides for Drug Delivery

Cited by 15 publications

References 98 publications

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Direct Powder Extrusion of Paracetamol Loaded Mixtures for 3D Printed Pharmaceutics for Personalized Medicine via Low Temperature Thermal Processing

Seaweed Polysaccharide-Based Nanoparticles: Preparation and Applications for Drug Delivery

5-Fluorouracil-Encapsulated Films Using Exopolysaccharides from a Thermophilic Bacterium Geobacillus sp. WSUCF1 for Topical Drug Delivery

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